INT125096

Context Info Confidence 0.03 First Reported 2005 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.14 Pain Relevance 0.10

cytosol (NEU2) small molecule metabolic process (NEU2) hydrolase activity, acting on glycosyl bonds (NEU2) cytoplasm (NEU2)

NEU2 (Homo sapiens)

Pain Link Frequency Relevance Heat Pain 1 70.32 TRP channel 1 68.72 Glutamate 46 5.00 Neurotransmitter 15 5.00 gABA 14 5.00 Dopamine 6 5.00 Central nervous system 5 5.00 Serotonin 3 5.00 headache 1 5.00 imagery 1 5.00

Disease Link Frequency Relevance Heat Pain 1 70.32 Stress 5 68.48 Hypoxia 33 5.00 Disease 6 5.00 Neurological Disease 3 5.00 Cerebral Hypoxia 3 5.00 Metabolic Disorder 2 5.00 Epilepsy 1 5.00 Maple Syrup Urine Disease 1 5.00 Dementia 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Truncation of TRPV1, expression of cytosolic termini of TRPV1 or TRPV4 and construction of chimeric TRPV channel subunits revealed that the specificity and the affinity of the subunit interaction is synergistically provided by interaction modules located in the transmembrane domains and in the cytosolic termini.

Gene_expression (expression) of cytosolic

1) Confidence 0.03 Published 2005 Journal J. Cell. Sci. Section Abstract Doc Link 15713749 Disease Relevance 0.07 Pain Relevance 0.10

Therefore, the dehydrogenation reaction in astrocytic mitochondria was added to the model in reverse direction (r151), allowing the transfer of cytosolic NADH to mitochondria in the form of FADH2.

Gene_expression (transfer) of cytosolic

2) Confidence 0.01 Published 2007 Journal Theor Biol Med Model Section Body Doc Link PMC2246127 Disease Relevance 0.07 Pain Relevance 0

General Comments

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