INT125244

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Context Info
Confidence 0.30
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.90
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
spinal cord 1
Ril2 (Mus musculus)
Pain Link Frequency Relevance Heat
intrathecal 2 99.98 Very High Very High Very High
Spinal cord 4 99.52 Very High Very High Very High
withdrawal 6 99.46 Very High Very High Very High
Morphine 4 99.24 Very High Very High Very High
narcan 4 98.62 Very High Very High Very High
cytokine 2 95.68 Very High Very High Very High
Central nervous system 22 5.00 Very Low Very Low Very Low
Multiple sclerosis 12 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Opiate Addiction 6 99.64 Very High Very High Very High
Cancer 69 92.76 High High
Hemangiosarcoma 13 91.84 High High
Weight Loss 2 89.32 High High
Diarrhoea 2 88.80 High High
Disease 22 84.20 Quite High
Recurrence 10 82.24 Quite High
Residual Neoplasm 2 61.96 Quite High
Sarcoma 49 50.00 Quite Low
Multiple Sclerosis 50 43.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, pcDNA3-IL-2 (8 microg DNA) had a similar effect as 1x10 IU rIL-2 protein on inhibition of morphine withdrawal syndrome in mice, and the expression of rIL-2 protein in spinal cord could be detected for 6 days.
Gene_expression (expression) of rIL-2 in spinal cord associated with withdrawal, spinal cord and morphine
1) Confidence 0.30 Published 2005 Journal Neuroreport Section Abstract Doc Link 15729143 Disease Relevance 0.43 Pain Relevance 0.43
The addition of rIL-2 resulted in recovery of the Foxp3+ Treg cells that had been decreased by vitamin D3 compared with the numbers of Treg cells in the TGF-?
Gene_expression (addition) of rIL-2
2) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944871 Disease Relevance 0 Pain Relevance 0
The naloxone-precipitated withdrawal syndrome in mice and rats after intrathecal injection of recombinant human interleukin-2 protein (rIL-2) or its gene was studied.
Gene_expression (injection) of rIL-2 associated with narcan, withdrawal and intrathecal
3) Confidence 0.26 Published 2005 Journal Neuroreport Section Abstract Doc Link 15729143 Disease Relevance 0.41 Pain Relevance 0.39
Ohguri et al used rIL-2
Gene_expression (used) of rIL-2
4) Confidence 0.04 Published 2006 Journal Sarcoma Section Body Doc Link PMC1510952 Disease Relevance 1.06 Pain Relevance 0.05

General Comments

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