INT125384

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Context Info
Confidence 0.49
First Reported 2004
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 23
Total Number 24
Disease Relevance 17.10
Pain Relevance 14.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
muscle 3
embryo 1
hematopoietic stem cell 1
synaptic cleft 1
chest 1
Pain1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 1121 100.00 Very High Very High Very High
Neuropathic pain 121 100.00 Very High Very High Very High
Lasting pain 86 100.00 Very High Very High Very High
Inflammation 86 100.00 Very High Very High Very High
IPN 67 100.00 Very High Very High Very High
Paroxysmal pain 5 100.00 Very High Very High Very High
Neuropeptide 15 99.54 Very High Very High Very High
nMDA receptor 6 98.96 Very High Very High Very High
Central nervous system 58 98.84 Very High Very High Very High
sodium channel 53 97.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 1219 100.00 Very High Very High Very High
Neuropathic Pain 173 100.00 Very High Very High Very High
INFLAMMATION 97 100.00 Very High Very High Very High
Inflammatory Pain 67 100.00 Very High Very High Very High
Infection 8 98.88 Very High Very High Very High
Pulmonary Disease 8 98.74 Very High Very High Very High
Vomiting 11 98.48 Very High Very High Very High
Bacterial Meningitis 1 98.28 Very High Very High Very High
Targeted Disruption 82 97.58 Very High Very High Very High
Barotrauma 20 97.14 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The most extensive experimentation was conducted with chlordecone and showed a dose-related, early appearance of elevated anti-dsDNA autoantibody titers and immune complex deposition in the kidneys.
Positive_regulation (elevated) of auto
1) Confidence 0.49 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1253759 Disease Relevance 0.48 Pain Relevance 0.04
This was accompanied by a decrease in frequency, which again has been reported previously (Williams et al., 1998; Chan and Yung, 1999, 2003), and is likely to be mediated by activation of presynaptic GABAB autoreceptors as a consequence of increased accumulation of GABA following uptake blockade (Chan and Yung, 1999, 2003).
Positive_regulation (activation) of auto associated with gaba
2) Confidence 0.45 Published 2010 Journal Neuroscience Section Body Doc Link PMC2877872 Disease Relevance 0 Pain Relevance 0.48
The initial activation of both somatodendritic 5-HT1A auto-receptors and the presynaptic 5-HT1B autoreceptors results in an inhibition of 5-HT release into the synaptic cleft.
Positive_regulation (activation) of auto in synaptic cleft
3) Confidence 0.45 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936309 Disease Relevance 0.15 Pain Relevance 0.46
h might be proved in the future in other models of surgery or other interventions that can induce persistent pain, noxious stimuli of moderate duration, or impairment of general condition and wellbeing.
Positive_regulation (induce) of pain associated with pain and lasting pain
4) Confidence 0.40 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2965018 Disease Relevance 0.58 Pain Relevance 0.51
To induce post-operative pain we performed a sham vasectomy or embryo transfer, both including a laparotomy (Martin et al., 2004; Arras et al., 2007; Roughan et al., 2009).
Positive_regulation (induce) of pain in embryo associated with pain
5) Confidence 0.37 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2965018 Disease Relevance 0.46 Pain Relevance 0.74
Similarly, there was in meniscectomized individuals evidence for a graded increase in pain and functional limitations with increasing severity of radiographic signs of OA [24].
Positive_regulation (increase) of pain associated with pain and osteoarthritis
6) Confidence 0.21 Published 2004 Journal Health Qual Life Outcomes Section Body Doc Link PMC509423 Disease Relevance 1.04 Pain Relevance 0.63
Expiratory muscle contraction can elevate auto-PEEP without adding to dynamic hyperinflation, and therefore for accurate measurement of auto-PEEP the patient should be relaxed.
Positive_regulation (elevate) of auto-PEEP in muscle
7) Confidence 0.11 Published 2005 Journal Crit Care Section Body Doc Link PMC1414026 Disease Relevance 0.53 Pain Relevance 0
We next assayed neuropathic pain induction in L-CKO mice.
Positive_regulation (induction) of pain associated with neuropathic pain
8) Confidence 0.09 Published 2010 Journal Mol Pain Section Body Doc Link PMC2919460 Disease Relevance 0.98 Pain Relevance 0.93
It has been demonstrated that in patients with chronic obstructive pulmonary disease more than 40% of inspiratory muscle effort can be expended to overcome auto-PEEP [41,42], and that adding extrinsic PEEP can attenuate the inspiratory muscle effort needed to trigger inspiration and improve patient–ventilator interaction.
Positive_regulation (overcome) of auto-PEEP in muscle associated with pulmonary disease
9) Confidence 0.08 Published 2005 Journal Crit Care Section Body Doc Link PMC1414026 Disease Relevance 0.45 Pain Relevance 0
In terms of reducing the work of breathing, the addition of extrinsic PEEP in patients with dynamic hyperinflation would theoretically reduce the inspiratory muscle effort required to overcome auto-PEEP and initiate an inspiration.
Positive_regulation (overcome) of auto-PEEP in muscle
10) Confidence 0.08 Published 2005 Journal Crit Care Section Body Doc Link PMC1414026 Disease Relevance 0.52 Pain Relevance 0.05
Other situations in which clinicians should suspect gas-trapping include increasing chest wall girth, hyperinflation on chest imaging, reduced efficiency of ventilation, increased patient effort, unexplained patient agitation, development of barotrauma, haemodynamic compromise and missed respiratory efforts (as patients attempt to trigger the ventilator but cannot generate enough pressure to overcome the auto-PEEP that has developed) [22].


Positive_regulation (overcome) of auto-PEEP in chest associated with barotrauma and imagery
11) Confidence 0.08 Published 2005 Journal Crit Care Section Body Doc Link PMC1414026 Disease Relevance 0.32 Pain Relevance 0.05
This result was remarkable considering a virtual abolishment of SNI-induced neuropathic pain in E-CKO mice [14].
Positive_regulation (induced) of pain associated with neuropathic pain
12) Confidence 0.07 Published 2010 Journal Mol Pain Section Body Doc Link PMC2919460 Disease Relevance 1.49 Pain Relevance 1.34
Uncovering two Runx1-dependent differentiation programs necessary for inflammatory and neuropathic pain
Positive_regulation (necessary) of pain associated with inflammation and neuropathic pain
13) Confidence 0.07 Published 2010 Journal Mol Pain Section Body Doc Link PMC2919460 Disease Relevance 0.37 Pain Relevance 1.07
Moreover, most patients experience pain relief.
Positive_regulation (experience) of pain associated with pain
14) Confidence 0.03 Published 2008 Journal Dig Dis Sci Section Body Doc Link PMC2467533 Disease Relevance 1.22 Pain Relevance 0.48
There were two patients, both of group II, which did not experience any pain during treatment.
Neg (not) Positive_regulation (experience) of pain associated with pain
15) Confidence 0.03 Published 2008 Journal Dig Dis Sci Section Body Doc Link PMC2467533 Disease Relevance 0.75 Pain Relevance 0.27
Subjects were asked to verbally rate each stimulus on a scale of 0 (no sensation) to 100 (most excruciating pain imaginable).


Positive_regulation (excruciating) of pain associated with pain
16) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964315 Disease Relevance 0.41 Pain Relevance 0.49
In order to obtain experimental confirmation and extension of findings, cortical processing of experimentally-induced pain was used.


Positive_regulation (induced) of pain associated with pain
17) Confidence 0.02 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2964315 Disease Relevance 0.77 Pain Relevance 0.68
In addition to experimentally induced pain, several studies have investigated the
               contribution of genetic variability to differences in severity of and susceptibility
               to chronic pain conditions. 
Positive_regulation (induced) of pain associated with pain and lasting pain
18) Confidence 0.01 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432024 Disease Relevance 1.17 Pain Relevance 1.09
Examples of transgenics that have generated
               insights into pain pathways are numerous, and include reports of modulation of pain
               behaviour by the overexpression of the neuropeptide galanin [28], and the enhancement of
               inflammatory pain by overexpression of the NMDA receptor subunit N2RB in the
               forebrain [29]. 
Positive_regulation (enhancement) of pain in forebrain associated with pain, nmda receptor, ipn and neuropeptide
19) Confidence 0.01 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432024 Disease Relevance 1.18 Pain Relevance 0.87
Rarer mutations that impede the
               inactivation of the channel seem to cause acute paroxysmal pain [8],[9]. 
Positive_regulation (cause) of pain associated with pain and paroxysmal pain
20) Confidence 0.01 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2432024 Disease Relevance 1.07 Pain Relevance 0.96

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