INT125586

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Context Info
Confidence 0.75
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 8.28
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Stmn1) cytosol (Stmn1) cytoskeleton (Stmn1)
intracellular (Stmn1) cytoplasm (Stmn1)
Anatomy Link Frequency
blood cells 2
embryos 1
fibroblasts 1
erythroblasts 1
epithelium 1
Stmn1 (Mus musculus)
Pain Link Frequency Relevance Heat
long-term potentiation 26 99.04 Very High Very High Very High
amygdala 21 96.52 Very High Very High Very High
cINOD 2 78.24 Quite High
Hippocampus 18 71.04 Quite High
Spinal cord 21 5.00 Very Low Very Low Very Low
medulla 12 5.00 Very Low Very Low Very Low
anesthesia 7 5.00 Very Low Very Low Very Low
midbrain 6 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
withdrawal 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 208 100.00 Very High Very High Very High
Targeted Disruption 98 99.92 Very High Very High Very High
Cancer 231 99.32 Very High Very High Very High
Hematological Disease 220 98.16 Very High Very High Very High
Cleidocranial Dysplasia 10 98.12 Very High Very High Very High
Sarcoma 14 97.84 Very High Very High Very High
Metastasis 22 97.76 Very High Very High Very High
Anxiety Disorder 47 97.60 Very High Very High Very High
Prostate Cancer 25 94.72 High High
Anaemia 50 94.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, neither Bcl-2, E1B-19K overexpression, nor p53 deficiency, could restore blood cell dysplasia, which was evidenced by the presence of immature erythrocytes (erythroblasts) and anemia (data not shown for Bcl-2 and E1B-19K).
Gene_expression (overexpression) of 19K in erythroblasts associated with anaemia and cleidocranial dysplasia
1) Confidence 0.75 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2561060 Disease Relevance 0.59 Pain Relevance 0
Induced p53 deficiency, as well as overexpression of the anti-apoptotic proteins Bcl-2 and E1B-19K, significantly relieves the decreased blood cells numbers caused by zTERT knockdown, but not the impaired blood cell differentiation.
Gene_expression (overexpression) of 19K in blood cell associated with apoptosis
2) Confidence 0.75 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2561060 Disease Relevance 0.61 Pain Relevance 0
The overexpression of Bcl-2 or E1B-19K was also found to counteract the reduction in the number of blood cells due to cytopenia.
Gene_expression (overexpression) of 19K in blood cells
3) Confidence 0.75 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2561060 Disease Relevance 0.69 Pain Relevance 0
Importantly, none of the interventions (p53 deficiency, Bcl-2, and E1B-19K) used in our present experiments that inhibit apoptosis were capable of restoring the insufficient differentiation and maturation of erythrocytes in the zTERT morphants (Figure 5E, and data not shown), suggesting that TERT is an essential component of certain processes underlying hematopoietic cell differentiation, regardless of the survival pathways that may be initiated.


Gene_expression (deficiency) of 19K in hematopoietic cell associated with apoptosis
4) Confidence 0.65 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2561060 Disease Relevance 0.65 Pain Relevance 0
The cytopenic phenotype, but not impaired differentiation, in the zTERT-deficient embryos is significantly reduced by the loss of p53 as well as by the expression of the anti-apoptotic proteins Bcl-2 and E1B-19K.
Gene_expression (expression) of 19K in embryos associated with apoptosis
5) Confidence 0.58 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2561060 Disease Relevance 0.93 Pain Relevance 0
It has been shown that stathmin overexpression in HeLa cells leads to Golgi fragmentation and microtubule disassembly, which are the same events observed in transgenic G93A SOD1 mice [56].
Gene_expression (overexpression) of stathmin in HeLa associated with targeted disruption
6) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844426 Disease Relevance 0.71 Pain Relevance 0
3, respectively), whereas the MT-destabilising protein stathmin (STMN1), is upregulated (?
Gene_expression (destabilising) of STMN1
7) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844426 Disease Relevance 0.08 Pain Relevance 0
3, respectively), whereas the MT-destabilising protein stathmin (STMN1), is upregulated (?
Gene_expression (destabilising) of stathmin
8) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844426 Disease Relevance 0.08 Pain Relevance 0
Much more intense were the smoke-induced alterations of a variety of intermediate biomarkers, such as cytogenetic end points in pulmonary alveolar macrophages, bone marrow and peripheral blood erythrocytes; apoptosis, p53 oncoprotein, and proliferating cell nuclear antigen in the bronchial epithelium; bulky DNA adducts, 8-hydroxy-2-deoxyguanosine; multigene expression, and thiobarbituric acid-reactive aldehydes in whole lung and several other organs.
Gene_expression (expression) of p53 oncoprotein in epithelium associated with apoptosis
9) Confidence 0.38 Published 2005 Journal Exp. Lung Res. Section Abstract Doc Link 15765917 Disease Relevance 0.57 Pain Relevance 0.08
Knockout of stathmin resulted in deficient amygdalar LTP and reduced cued and contextual fear conditioning as well as increased exploration of the open arm in the elevated plus maze.
Gene_expression (resulted) of stathmin in arm associated with targeted disruption, anxiety disorder and long-term potentiation
10) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2707006 Disease Relevance 1.03 Pain Relevance 0.35
Moreover, it has been shown that microtubule destabilization through stathmin overexpression can also lead to acquisition of amoeboid movement in sarcoma cells and that the tumor suppressor protein p27kip1 is an important factor for the control of cellular morphology and motility of transformed fibroblasts by regulating microtubule stability [38], [39].
Gene_expression (overexpression) of stathmin in fibroblasts associated with sarcoma and cancer
11) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3014295 Disease Relevance 0.72 Pain Relevance 0
In the same system, stathmin overexpression increased tubulin levels.
Gene_expression (overexpression) of stathmin
12) Confidence 0.05 Published 2008 Journal PPAR Research Section Body Doc Link PMC2396401 Disease Relevance 0.20 Pain Relevance 0
In this study, re-expression of ADAMTS1 in LNCaP-19 greatly delayed tumor establishment, indicating that ADAMTS1 actually might function as a tumor suppressor of androgen-independent prostate tumors.
Gene_expression (expression) of LNCaP-19 associated with cancer and prostate cancer
13) Confidence 0.01 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2894797 Disease Relevance 1.42 Pain Relevance 0

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