INT125587

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Context Info
Confidence 0.67
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 4.20
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Stmn1) cytosol (Stmn1) cytoskeleton (Stmn1)
intracellular (Stmn1) cytoplasm (Stmn1)
Anatomy Link Frequency
blood cell 6
fibroblasts 2
erythroblasts 2
epithelium 2
Stmn1 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 2 78.24 Quite High
Spinal cord 14 5.00 Very Low Very Low Very Low
medulla 8 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
midbrain 4 5.00 Very Low Very Low Very Low
withdrawal 4 5.00 Very Low Very Low Very Low
Hippocampus 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 168 100.00 Very High Very High Very High
Sprains And Strains 2 98.84 Very High Very High Very High
Cleidocranial Dysplasia 8 98.12 Very High Very High Very High
Sarcoma 14 97.84 Very High Very High Very High
Cancer 116 96.76 Very High Very High Very High
Anaemia 40 94.44 High High
Hematological Disease 176 94.00 High High
Lung Cancer 4 90.00 High High
Pancytopenia 28 82.40 Quite High
Death 33 77.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, neither Bcl-2, E1B-19K overexpression, nor p53 deficiency, could restore blood cell dysplasia, which was evidenced by the presence of immature erythrocytes (erythroblasts) and anemia (data not shown for Bcl-2 and E1B-19K).
Neg (neither) Positive_regulation (overexpression) of Gene_expression (overexpression) of 19K in erythroblasts associated with anaemia and cleidocranial dysplasia
1) Confidence 0.67 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2561060 Disease Relevance 0.59 Pain Relevance 0
The overexpression of Bcl-2 or E1B-19K was also found to counteract the reduction in the number of blood cells due to cytopenia.
Positive_regulation (overexpression) of Gene_expression (overexpression) of 19K in blood cells
2) Confidence 0.67 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2561060 Disease Relevance 0.69 Pain Relevance 0
Induced p53 deficiency, as well as overexpression of the anti-apoptotic proteins Bcl-2 and E1B-19K, significantly relieves the decreased blood cells numbers caused by zTERT knockdown, but not the impaired blood cell differentiation.
Positive_regulation (overexpression) of Gene_expression (overexpression) of 19K in blood cell associated with apoptosis
3) Confidence 0.67 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2561060 Disease Relevance 0.61 Pain Relevance 0
Induced p53 deficiency, as well as overexpression of the anti-apoptotic proteins Bcl-2 and E1B-19K, significantly relieves the decreased blood cells numbers caused by zTERT knockdown, but not the impaired blood cell differentiation.
Positive_regulation (overexpression) of Gene_expression (overexpression) of 19K in blood cell associated with apoptosis
4) Confidence 0.49 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2561060 Disease Relevance 0.61 Pain Relevance 0
3, respectively), whereas the MT-destabilising protein stathmin (STMN1), is upregulated (?
Positive_regulation (upregulated) of Gene_expression (destabilising) of STMN1
5) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844426 Disease Relevance 0.08 Pain Relevance 0
3, respectively), whereas the MT-destabilising protein stathmin (STMN1), is upregulated (?
Positive_regulation (upregulated) of Gene_expression (destabilising) of stathmin
6) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2844426 Disease Relevance 0.08 Pain Relevance 0
Much more intense were the smoke-induced alterations of a variety of intermediate biomarkers, such as cytogenetic end points in pulmonary alveolar macrophages, bone marrow and peripheral blood erythrocytes; apoptosis, p53 oncoprotein, and proliferating cell nuclear antigen in the bronchial epithelium; bulky DNA adducts, 8-hydroxy-2-deoxyguanosine; multigene expression, and thiobarbituric acid-reactive aldehydes in whole lung and several other organs.
Positive_regulation (smoke-induced) of Gene_expression (expression) of p53 oncoprotein in epithelium associated with apoptosis
7) Confidence 0.29 Published 2005 Journal Exp. Lung Res. Section Abstract Doc Link 15765917 Disease Relevance 0.61 Pain Relevance 0.08
Moreover, it has been shown that microtubule destabilization through stathmin overexpression can also lead to acquisition of amoeboid movement in sarcoma cells and that the tumor suppressor protein p27kip1 is an important factor for the control of cellular morphology and motility of transformed fibroblasts by regulating microtubule stability [38], [39].
Positive_regulation (overexpression) of Gene_expression (overexpression) of stathmin in fibroblasts associated with sarcoma and cancer
8) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3014295 Disease Relevance 0.72 Pain Relevance 0
In the same system, stathmin overexpression increased tubulin levels.
Positive_regulation (overexpression) of Gene_expression (overexpression) of stathmin
9) Confidence 0.04 Published 2008 Journal PPAR Research Section Body Doc Link PMC2396401 Disease Relevance 0.20 Pain Relevance 0

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