INT125767

Context Info Confidence 0.49 First Reported 2005 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 6 Total Number 6 Disease Relevance 4.08 Pain Relevance 1.52

extracellular space (S100b) nucleus (S100b) cytoplasm (S100b)

Anatomy Link Frequency brain 4 astrocytes 4 nerve 2 S100b (Rattus norvegicus)

Pain Link Frequency Relevance Heat cytokine 29 99.88 dorsal root ganglion 36 98.20 Sciatic nerve 55 96.88 ischemia 40 92.28 Inflammatory response 23 82.52 Inflammatory marker 1 81.40 cINOD 6 68.36 cerebral cortex 18 67.68 nav1.8 6 65.20 Inflammation 50 53.04

Disease Link Frequency Relevance Heat Myocardial Infarction 42 98.96 Ganglion Cysts 36 98.20 Disease 140 97.28 Reperfusion Injury 6 93.04 Cv General 4 Under Development 24 92.28 Hypothermia 66 91.04 Nerve Compression Syndromes 31 89.28 Headache 4 87.68 Lewy Body Disease 66 86.84 INFLAMMATION 74 82.12

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

RESULTS: Total and degraded GFAP content and S100B protein expression in different areas of brain tissues significantly increased in diabetic rats compared to control rats.

Positive_regulation (increased) of Gene_expression (expression) of S100B protein in brain

1) Confidence 0.49 Published 2005 Journal Acta Pharmacol. Sin. Section Body Doc Link 15780189 Disease Relevance 0.08 Pain Relevance 0

RESULTS: During migraine attacks elevated s100b levels could be observed.

Positive_regulation (elevated) of Gene_expression (levels) of s100b

2) Confidence 0.33 Published 2009 Journal Headache Section Body Doc Link 18783450 Disease Relevance 0.09 Pain Relevance 0

This was based on our demonstration that activated microglia overexpressing interleukin-1 (IL-1), a potent immune response-generating cytokine, and activated astrocytes overexpressing S100B, a cytokine that promotes excessive neurite growth, in Alzheimer’s disease (Griffin et al 1989).

Positive_regulation (overexpressing) of Gene_expression (overexpressing) of S100B in astrocytes associated with disease and cytokine

3) Confidence 0.32 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656298 Disease Relevance 0.98 Pain Relevance 0.28

Interestingly, although s100B expression was strong in nerve cultures, it was still stronger in DRG cultures (Fig. 5E).

Positive_regulation (strong) of Gene_expression (expression) of s100B in nerve associated with dorsal root ganglion

4) Confidence 0.29 Published 2009 Journal Mol Pain Section Body Doc Link PMC2667430 Disease Relevance 0.53 Pain Relevance 0.60

This was based on our demonstration that activated microglia overexpressing interleukin-1 (IL-1), a potent immune response-generating cytokine, and activated astrocytes overexpressing S100B, a cytokine that promotes excessive neurite growth, in Alzheimer’s disease (Griffin et al 1989).

Positive_regulation (activated) of Gene_expression (overexpressing) of S100B in astrocytes associated with disease and cytokine

5) Confidence 0.23 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656298 Disease Relevance 0.99 Pain Relevance 0.28

Concerning reliable biochemical markers of brain tissue damage, increased serum levels of the low molecular weight protein S100B have been reported after cardiac arrest correlating with neurological complications.

Positive_regulation (increased) of Gene_expression (levels) of protein S100B in brain associated with myocardial infarction

6) Confidence 0.02 Published 2010 Journal Crit Care Section Body Doc Link PMC2875536 Disease Relevance 1.42 Pain Relevance 0.36

General Comments

This test has worked.