INT125772

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Context Info
Confidence 0.42
First Reported 2005
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.40
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Serpine1) extracellular region (Serpine1)
Anatomy Link Frequency
sciatic nerve 2
Serpine1 (Mus musculus)
Pain Link Frequency Relevance Heat
Sciatic nerve 1 99.12 Very High Very High Very High
Neuropathic pain 1 97.08 Very High Very High Very High
Peripheral nerve injury 1 75.00 Quite High
Root ganglion neuron 1 75.00 Quite High
neuralgia 2 25.00 Low Low
cINOD 4 5.00 Very Low Very Low Very Low
COX-2 inhibitor 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
peptic ulcer disease 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuropathic Pain 1 97.08 Very High Very High Very High
Injury 3 79.44 Quite High
Nervous System Injury 2 75.00 Quite High
Ganglion Cysts 1 75.00 Quite High
Incontinence 1 19.00 Low Low
Dysgeusia 1 18.32 Low Low
Exanthema 1 17.72 Low Low
Vomiting 2 17.48 Low Low
Diarrhoea 2 17.16 Low Low
Heart Rate Under Development 2 12.60 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
uPA levels in postmenopausal women increase, while PAI-1 and PGE2 decrease, after treatment with high dose celecoxib
Positive_regulation (increase) of Negative_regulation (decrease) of PAI-1
1) Confidence 0.42 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2580770 Disease Relevance 0 Pain Relevance 0
Here we examined whether the plasminogen activator inhibitor-1 and -2 (PAI-1 and PAI-2) mRNA, endogenous inhibitors of tPA and uPA, are induced in the DRG following sciatic nerve transection.
Spec (whether) Positive_regulation (induced) of Spec (whether) Negative_regulation (inhibitors) of PAI-1 in sciatic nerve associated with sciatic nerve
2) Confidence 0.08 Published 2005 Journal Neuroscience Section Abstract Doc Link 15780477 Disease Relevance 0.40 Pain Relevance 0.22

General Comments

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