INT125791

Context Info Confidence 0.22 First Reported 2005 Last Reported 2005 Negated 1 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.09 Pain Relevance 0.52

cytosol (Ldha) mitochondrion (Ldha) oxidoreductase activity (Ldha) carbohydrate metabolic process (Ldha) cytoplasm (Ldha)

Anatomy Link Frequency macrophages 2 Ldha (Mus musculus)

Pain Link Frequency Relevance Heat ketamine 15 97.94 anesthesia 1 82.56 cytokine 1 25.00 Inflammation 1 25.00

Disease Link Frequency Relevance Heat Death 1 90.48 INFLAMMATION 1 25.00 Toxicity 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Exposure of macrophages to 10 and 100 microM ketamine, which correspond to 0.1 and 1 times the clinically relevant concentration, for 1, 6, and 24 h had no effect on cell viability or lactate dehydrogenase release.

Neg (no) Regulation (effect) of Localization (release) of lactate dehydrogenase in macrophages associated with ketamine

1) Confidence 0.22 Published 2005 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 15781291 Disease Relevance 0.09 Pain Relevance 0.52

General Comments

This test has worked.