INT12598

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Context Info
Confidence 0.48
First Reported 1991
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 20
Total Number 24
Disease Relevance 13.11
Pain Relevance 3.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (DBP)
Anatomy Link Frequency
blood 1
chromaffin cells 1
DBP (Homo sapiens)
Pain Link Frequency Relevance Heat
Gabapentin 10 100.00 Very High Very High Very High
cINOD 5 100.00 Very High Very High Very High
adenocard 1 99.98 Very High Very High Very High
agonist 3 99.24 Very High Very High Very High
local anesthetic 4 99.06 Very High Very High Very High
Calcium channel 9 98.68 Very High Very High Very High
anticonvulsant 2 97.08 Very High Very High Very High
Pain 15 93.48 High High
substance P 3 91.72 High High
Potency 1 89.12 High High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 61 100.00 Very High Very High Very High
Obesity 31 100.00 Very High Very High Very High
Primary Sclerosing Cholangitis 1 99.92 Very High Very High Very High
Sepsis 10 99.74 Very High Very High Very High
Hypertension 94 99.72 Very High Very High Very High
Disorder Of Lipid Metabolism 33 99.54 Very High Very High Very High
Cardiovascular Disease 55 97.74 Very High Very High Very High
Multiple Trauma 5 97.72 Very High Very High Very High
Acute Liver Failure 5 96.88 Very High Very High Very High
Renal Disease 8 96.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Vitamin D-binding protein (DBP) binds, transports and activates vitamin D, which plays a major role in calcium homeostasis and bone turnover.
DBP Binding (binds) of
1) Confidence 0.48 Published 2007 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 17347552 Disease Relevance 0.65 Pain Relevance 0.09
DBP specifically interacts with arachidonic acid, a precursor of prostaglandins [23].
DBP Binding (interacts) of
2) Confidence 0.41 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2989318 Disease Relevance 0.78 Pain Relevance 0.13
Memantine, at therapeutic concentrations, probably does not interact with the sigma binding site.
sigma binding site Neg (not) Binding (interact) of
3) Confidence 0.39 Published 1993 Journal Neurosci. Lett. Section Abstract Doc Link 8309617 Disease Relevance 0.40 Pain Relevance 0.09
Amlodipine significantly reduced ambulatory BP values compared with baseline values: mean decreases in 24-hour, daytime, and nighttime SBP/DBP were: ?
DBP Binding (nighttime) of
4) Confidence 0.37 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835558 Disease Relevance 0 Pain Relevance 0
Patients with sitting DBP ?
DBP Binding (Patients) of
5) Confidence 0.32 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2835558 Disease Relevance 0.90 Pain Relevance 0.10
In the actin scavenging system, gelsolin depolymerizes F-actin and DBP binds monomeric G-actin in order to prevent polymerization.
DBP Binding (binds) of
6) Confidence 0.32 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2989318 Disease Relevance 1.08 Pain Relevance 0.07
Other conditions such as septic shock may also be associated with reduced DBP levels and complex formation with actin [19].
DBP Binding (formation) of associated with sepsis
7) Confidence 0.32 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2989318 Disease Relevance 0.75 Pain Relevance 0.10
Other conditions such as septic shock may also be associated with reduced DBP levels and complex formation with actin [19].
DBP Binding (associated) of associated with sepsis
8) Confidence 0.32 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2989318 Disease Relevance 0.75 Pain Relevance 0.09
In addition to actin, gelsolin and DBP bind important bioactive lipids.
DBP Binding (bind) of
9) Confidence 0.31 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2989318 Disease Relevance 0.75 Pain Relevance 0.11
As part of a program to investigate the structure-activity relationships of Gabapentin (Neurontin), a number of alkylated analogues were synthesized and evaluated in vitro for binding to the Gabapentin binding site located on the alpha2delta subunit of a calcium channel.
Gabapentin binding site Binding (binding) of associated with calcium channel and gabapentin
10) Confidence 0.26 Published 1998 Journal J. Med. Chem. Section Abstract Doc Link 9599234 Disease Relevance 0.08 Pain Relevance 0.54
Identification of novel ligands for the gabapentin binding site on the alpha2delta subunit of a calcium channel and their evaluation as anticonvulsant agents.
gabapentin binding site Binding (ligands) of associated with calcium channel, anticonvulsant and gabapentin
11) Confidence 0.24 Published 1998 Journal J. Med. Chem. Section Title Doc Link 9599234 Disease Relevance 0.08 Pain Relevance 0.57
The hairpin that forms from the top strand of the enhancer and contains two GT mispaired bases creates an alternative binding site for the cyclic adenosine monophosphate element binding protein (CREB), a transcription factor that binds to and regulates the human proenkephalin gene.
monophosphate element binding protein Binding (binds) of associated with adenocard
12) Confidence 0.19 Published 1994 Journal Biochemistry Section Abstract Doc Link 7918415 Disease Relevance 0 Pain Relevance 0.12
Most cardiovascular disease is associated with BP levels below the current definition of hypertension (WHO 2002), and there is a continuous association between usual BP and cardiovascular event risk down to 115 mm Hg SBP and 75 mm Hg DBP (PSC 2000).
DBP Binding (association) of associated with cardiovascular disease, primary sclerosing cholangitis and hypertension
13) Confidence 0.19 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1993997 Disease Relevance 1.08 Pain Relevance 0
High total cholesterol and triglycerides are associated with high SBP and DBP, and LDL marginally predicts higher DBP.
DBP Binding (associated) of associated with disorder of lipid metabolism
14) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722089 Disease Relevance 0.90 Pain Relevance 0
Three-way interactions emerged for SBP and DBP: Only for those in expressive suppression condition, anger-out was related significantly to SBP during and following cold pressor and to DBP following cold pressor.
DBP Binding (interactions) of
15) Confidence 0.14 Published 2007 Journal Ann Behav Med Section Body Doc Link 17927554 Disease Relevance 0 Pain Relevance 0
Up to date, only a limited number of in silico models for the prediction of albumin protein binding are available.
albumin protein Binding (binding) of
16) Confidence 0.11 Published 2005 Journal J. Med. Chem. Section Abstract Doc Link 15801837 Disease Relevance 0.09 Pain Relevance 0.09
In addition, in a subgroup analysis, a 50% reduction in major CV events was observed in patients with hypertension and diabetes randomized to a target DBP of ?
DBP Binding (randomized) of associated with diabetes mellitus and hypertension
17) Confidence 0.10 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994025 Disease Relevance 1.33 Pain Relevance 0
The genotypes were not associated with gender, duration of diabetes, age, diabetes treatment, BMI, HbA1c and fasting blood glucose levels, SBP, DBP, serum levels of total cholesterol, triglycerides, HDL cholesterol, low-density lipoprotein (LDL) cholesterol and creatinine.
DBP Neg (not) Binding (associated) of in blood associated with diabetes mellitus, obesity and disorder of lipid metabolism
18) Confidence 0.07 Published 2006 Journal Diabetic Medicine Section Body Doc Link PMC1619898 Disease Relevance 1.87 Pain Relevance 0
BiP is a chaperone protein containing a polypeptide binding site recognizing specific heptapeptide sequence and an ATP binding site.
ATP binding site Binding (recognizing) of
19) Confidence 0.04 Published 2001 Journal FASEB J. Section Abstract Doc Link 11689471 Disease Relevance 0.15 Pain Relevance 0.30
Nicotinic agonist (carbamylcholine) did not displace [125I]-catestatin from chromaffin cells, nor did catestatin displace the nicotinic agonist [3H]-epibatidine; these observations indicate a catestatin binding site separate from the agonist binding pocket on the nicotinic receptor, a finding consistent with catestatin's non-competitive nicotinic mechanism. [125I]-catestatin could be displaced from chromaffin cells by substance P (IC(50) approximately 5 microM), though at far lower potency than displacement by catestatin itself (IC(50) approximately 350-380 nM), suggesting that catestatin and substance P occupy an identical or overlapping non-competitive site on the nicotinic receptor, at different affinities (catestatin > substance P).
catestatin binding site Binding (indicate) of in chromaffin cells associated with agonist, potency and substance p
20) Confidence 0.04 Published 2000 Journal Regul. Pept. Section Abstract Doc Link 11062327 Disease Relevance 0 Pain Relevance 0.47

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