INT126500

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Context Info
Confidence 0.44
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.12
Pain Relevance 2.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (GRIN1)
Anatomy Link Frequency
oocytes 2
GRIN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
nMDA receptor 11 100.00 Very High Very High Very High
tramadol 9 100.00 Very High Very High Very High
gABA 3 100.00 Very High Very High Very High
Neurotransmitter 2 100.00 Very High Very High Very High
agonist 20 99.98 Very High Very High Very High
Antinociceptive 12 96.44 Very High Very High Very High
antiallodynic 57 96.16 Very High Very High Very High
antagonist 22 94.16 High High
Central nervous system 2 93.44 High High
monoamine 1 92.24 High High
Disease Link Frequency Relevance Heat
Hypersensitivity 24 63.64 Quite High
Pain 13 58.04 Quite High
Nociception 16 5.00 Very Low Very Low Very Low
Neuropathic Pain 14 5.00 Very Low Very Low Very Low
Neuroblastoma 2 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low
Hyperalgesia 1 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low
Dislocations 1 5.00 Very Low Very Low Very Low
Headache 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We tested the effects of tramadol and its M1 metabolite (0.1-100 microM) on human recombinant neurotransmitter-gated ion channels, including glycine, gamma-aminobutyric acid(A) (GABA(A)), and N-methyl-D-aspartate (NMDA) receptors, expressed in Xenopus oocytes.
Regulation (effects) of Gene_expression (expressed) of NMDA in oocytes associated with tramadol, gaba and neurotransmitter
1) Confidence 0.44 Published 2005 Journal Anesth. Analg. Section Abstract Doc Link 15845694 Disease Relevance 0 Pain Relevance 1.32
1 receptor agonists facilitated several NMDA receptor-mediated electrophysiological effects and that HP and other ?
Regulation (facilitated) of Gene_expression (receptor) of NMDA associated with nmda receptor and agonist
2) Confidence 0.44 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2695546 Disease Relevance 0.12 Pain Relevance 0.69

General Comments

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