INT126530

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Context Info
Confidence 0.43
First Reported 2002
Last Reported 2006
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.62
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Serpine1) extracellular region (Serpine1)
Serpine1 (Mus musculus)
Pain Link Frequency Relevance Heat
guanethidine 1 99.28 Very High Very High Very High
agonist 7 90.96 High High
Clonidine 1 86.32 High High
Central nervous system 1 84.60 Quite High
Neurotransmitter 1 83.40 Quite High
Glutamate 3 81.32 Quite High
cytokine 5 78.40 Quite High
Inflammation 29 67.40 Quite High
cva 3 47.92 Quite Low
Inflammatory mediators 2 32.40 Quite Low
Disease Link Frequency Relevance Heat
Sepsis 16 97.04 Very High Very High Very High
Diabetes Mellitus 136 94.56 High High
Prediabetic State 36 94.16 High High
Insulin Resistance 50 94.00 High High
Metabolic Syndrome 49 93.84 High High
Atherosclerosis 29 87.04 High High
Thrombosis 34 86.84 High High
Hypothermia 46 82.32 Quite High
Necrosis 2 79.92 Quite High
Cancer 5 79.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have found that the elevation of PAI-1 mRNA levels, as detected 3 h after systemic administration of kainate, was reduced by mecamylamine, guanethidine and phentolamine, but not by propranolol or atropine.
Neg (not) Negative_regulation (reduced) of Positive_regulation (elevation) of PAI-1 associated with guanethidine
1) Confidence 0.43 Published 2005 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 15850565 Disease Relevance 0.07 Pain Relevance 0.31
In sepsis, both the coagulation and the fibrinolytic system may be affected, as indicated by decreased activation of thrombomodulin and protein C as well as reduction of anti-fibrinolysis and enhancement of plasminogen activator inhibitor (PAI)-1 expression [2].
Negative_regulation (reduction) of Positive_regulation (enhancement) of PAI associated with sepsis
2) Confidence 0.36 Published 2006 Journal Crit Care Section Body Doc Link PMC1751084 Disease Relevance 1.15 Pain Relevance 0.07
PAI-1 elevations decrease the conversion of plasminogen to plasmin because it inhibits tPA and uPA.
Negative_regulation (decrease) of Positive_regulation (elevations) of PAI-1
3) Confidence 0.05 Published 2002 Journal Cardiovasc Diabetol Section Body Doc Link PMC140143 Disease Relevance 1.39 Pain Relevance 0

General Comments

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