INT126609

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Context Info
Confidence 0.69
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0.26
Pain Relevance 1.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Stat5a) signal transduction (Stat5a) nucleolus (Stat5a)
nucleus (Stat5a) DNA binding (Stat5a) cytoplasm (Stat5a)
Stat5a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 3 100.00 Very High Very High Very High
opioid receptor 27 99.74 Very High Very High Very High
Enkephalin 3 98.00 Very High Very High Very High
Morphine 3 97.08 Very High Very High Very High
MU agonist 3 93.20 High High
Disease Link Frequency Relevance Heat
Bordatella Infection 3 98.02 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we demonstrate that acute morphine or [D-Ala(2),N-Me-Phe(4),Gly(5)-ol]enkephalin (DAMGO) exposure of COS-7 cells transiently transfected with the micro-opioid receptor and STAT5A, leads to receptor-dependent tyrosine phosphorylation of STAT5A.
Positive_regulation (leads) of Phosphorylation (phosphorylation) of STAT5A associated with opioid receptor, enkephalin and morphine
1) Confidence 0.69 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15857395 Disease Relevance 0.09 Pain Relevance 0.59
STAT5A interacts with and is phosphorylated upon activation of the mu-opioid receptor.
Positive_regulation (activation) of Phosphorylation (phosphorylated) of STAT5A associated with opioid receptor
2) Confidence 0.50 Published 2005 Journal J. Neurochem. Section Title Doc Link 15857395 Disease Relevance 0.08 Pain Relevance 0.56
Pertussis toxin has no effect on the level of STAT5A phosphorylation, while the Src inhibitor PP1 abolishes opioid-dependent STAT5A phosphorylation.
Positive_regulation (opioid-dependent) of Phosphorylation (phosphorylation) of STAT5A associated with bordatella infection and opioid
3) Confidence 0.50 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 15857395 Disease Relevance 0.10 Pain Relevance 0.64

General Comments

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