INT126660

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Context Info
Confidence 0.50
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 0.07
Pain Relevance 1.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Tph1)
Anatomy Link Frequency
oocytes 4
neurons 2
serotonergic neurons 2
embryos 1
cumulus cells 1
Tph1 (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 79 99.80 Very High Very High Very High
medulla 1 98.16 Very High Very High Very High
monoamine 4 97.96 Very High Very High Very High
Raphe 8 95.36 Very High Very High Very High
antidepressant 9 75.00 Quite High
fluoxetine 24 42.96 Quite Low
sSRI 3 39.12 Quite Low
primary somatosensory cortex 2 9.28 Low Low
Hippocampus 16 5.00 Very Low Very Low Very Low
Eae 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Handedness 24 67.24 Quite High
Anxiety Disorder 29 50.00 Quite Low
Neurodegenerative Disease 19 50.00 Quite Low
Depression 7 5.00 Very Low Very Low Very Low
Ganglion Cysts 6 5.00 Very Low Very Low Very Low
Stress 4 5.00 Very Low Very Low Very Low
Autism 3 5.00 Very Low Very Low Very Low
Mental Disorders 3 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low
Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To clarify this possibility, we investigated mouse cumulus cells, oocytes, and embryos for three key serotonergic components, namely, 5-HT itself; the rate-limiting enzyme for its production, tryptophan hydroxylase 1 (TPH1); and the 5-HT-specific transporter (SLC6A4) required for modulating its cellular effects.
Positive_regulation (required) of Gene_expression (production) of TPH1 in oocytes
1) Confidence 0.50 Published 2005 Journal Biol. Reprod. Section Abstract Doc Link 15858217 Disease Relevance 0 Pain Relevance 0.14
Assay for TPH activity
Positive_regulation (Assay) of Gene_expression (activity) of TPH
2) Confidence 0.30 Published 2009 Journal Mol Brain Section Body Doc Link PMC2673217 Disease Relevance 0 Pain Relevance 0.05
The transcription factor Pet1 is expressed in serotonergic neurons and directly activates the transcription of genes that are involved in the synthesis (Tph and Aadc) and uptake (Sert) of serotonin.
Positive_regulation (activates) of Gene_expression (synthesis) of Tph in serotonergic neurons associated with serotonin
3) Confidence 0.19 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0 Pain Relevance 0.57
These neurons do not express tryptophan hydroxylase (Tph) or dopa decarboxylase (Aadc), which are required for serotonin synthesis, or the catabolic enzymes monoamine oxidase A and B.
Positive_regulation (required) of Gene_expression (express) of Tph in neurons associated with serotonin and monoamine
4) Confidence 0.19 Published 2010 Journal EMBO J Section Body Doc Link PMC2944059 Disease Relevance 0.07 Pain Relevance 0.39
To clarify this possibility, we investigated mouse cumulus cells, oocytes, and embryos for three key serotonergic components, namely, 5-HT itself; the rate-limiting enzyme for its production, tryptophan hydroxylase 1 (TPH1); and the 5-HT-specific transporter (SLC6A4) required for modulating its cellular effects.
Positive_regulation (required) of in cumulus cells Gene_expression (production) of TPH1 in oocytes
5) Confidence 0.17 Published 2005 Journal Biol. Reprod. Section Abstract Doc Link 15858217 Disease Relevance 0 Pain Relevance 0.14
To clarify this possibility, we investigated mouse cumulus cells, oocytes, and embryos for three key serotonergic components, namely, 5-HT itself; the rate-limiting enzyme for its production, tryptophan hydroxylase 1 (TPH1); and the 5-HT-specific transporter (SLC6A4) required for modulating its cellular effects.
Positive_regulation (required) of in embryos Gene_expression (production) of TPH1 in oocytes
6) Confidence 0.17 Published 2005 Journal Biol. Reprod. Section Abstract Doc Link 15858217 Disease Relevance 0 Pain Relevance 0.14

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