INT126661

Context Info Confidence 0.65 First Reported 2005 Last Reported 2006 Negated 1 Speculated 0 Reported most in Body Documents 6 Total Number 6 Disease Relevance 0.59 Pain Relevance 0.11

nucleus (RNF130) ligase activity (RNF130) cytoplasm (RNF130)

Anatomy Link Frequency platelet 5 RNF130 (Homo sapiens)

Pain Link Frequency Relevance Heat aspirin 5 80.24 withdrawal 1 72.60 Angina 11 50.00 antagonist 1 40.96 adenocard 1 25.00

Disease Link Frequency Relevance Heat Adhesions 1 99.12 Cv General 3 Under Development 11 96.40 Hemorrhage 1 82.08 Acute Coronary Syndrome 5 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The platelet tests uniformly revealed rebound activation by all platelet measures (at least twofold increase) while being especially high for ADP-, and collagen-induced aggregation, platelet/endothelial cell adhesion molecule-1 (PECAM-1), glycoprotein (GP)Ib, GPIIb/IIIa activity, P-selectin, protease activated receptor (PAR)-1 thrombin receptor (activated and intact epitopes), and thrombospondin expression.

Gene_expression (expression) of GP in platelet associated with adhesions

1) Confidence 0.65 Published 2006 Journal Int. J. Clin. Pract. Section Abstract Doc Link 16846403 Disease Relevance 0.18 Pain Relevance 0.11

There was no significantly different in platelet GP IIb/IIIa expression after the antiplatelet therapy in patients with unstable angina.

Neg (no) Gene_expression (expression) of GP in platelet

2) Confidence 0.58 Published 2005 Journal Pol. Merkur. Lekarski Section Body Doc Link 15859538 Disease Relevance 0.06 Pain Relevance 0

THE AIM: To estimate by flow cytometry GP IIb/IIIa expression on the platelets and platelet microparticles membrane.

Gene_expression (expression) of GP in platelet

3) Confidence 0.58 Published 2005 Journal Pol. Merkur. Lekarski Section Body Doc Link 15859538 Disease Relevance 0.10 Pain Relevance 0

In group B2- before treatment- the percentage of platelet expressing GP IIb/IIIa was lower (60.1%) than in the group B1.

Gene_expression (expressing) of GP in platelet

4) Confidence 0.58 Published 2005 Journal Pol. Merkur. Lekarski Section Body Doc Link 15859538 Disease Relevance 0.08 Pain Relevance 0

RESULTS: Patients with unstable angina in group B1 were by 12% higher expression of GP IIb/IIIa than control group (62.6 vs 55.1%).

Gene_expression (expression) of GP

5) Confidence 0.58 Published 2005 Journal Pol. Merkur. Lekarski Section Body Doc Link 15859538 Disease Relevance 0.08 Pain Relevance 0

THE AIM: To estimate by flow cytometry GP IIb/IIIa expression on the platelets and platelet microparticles membrane.

Gene_expression (expression) of GP in platelets

6) Confidence 0.20 Published 2005 Journal Pol. Merkur. Lekarski Section Body Doc Link 15859538 Disease Relevance 0.10 Pain Relevance 0

General Comments

This test has worked.