INT126717

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Context Info
Confidence 0.21
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 3.35
Pain Relevance 2.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6, Il6st) signal transduction (Il6st) aging (Il6)
extracellular region (Il6) cellular_component (Il6st)
Il6 (Rattus norvegicus)
Il6st (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 14 100.00 Very High Very High Very High
antagonist 6 100.00 Very High Very High Very High
Peripheral nerve injury 2 99.60 Very High Very High Very High
agonist 3 99.56 Very High Very High Very High
rheumatoid arthritis 3 94.72 High High
Arthritis 153 94.48 High High
Inflammation 90 94.44 High High
dorsal root ganglion 4 91.52 High High
Spinal cord 4 84.32 Quite High
IPN 3 76.96 Quite High
Disease Link Frequency Relevance Heat
Nervous System Injury 2 98.72 Very High Very High Very High
Rheumatoid Arthritis 3 94.72 High High
Arthritis 177 94.48 High High
INFLAMMATION 81 94.44 High High
Necrosis 6 90.60 High High
Ganglion Cysts 4 90.56 High High
Cancer 6 90.24 High High
Inflammatory Pain 3 76.96 Quite High
Neuropathic Pain 6 75.00 Quite High
Diabetic Nephropathy 4 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interleukin-6 (IL-6) is a pleiotropic cytokine, signaling intracellularly via its unique membrane-bound receptor IL-6R and gp130.
IL-6 Binding (bound) of gp130 associated with cytokine
1) Confidence 0.21 Published 2005 Journal Cytokine Section Abstract Doc Link 15863388 Disease Relevance 0.39 Pain Relevance 0.35
Interleukin-6 (IL-6) is a pleiotropic cytokine, signaling intracellularly via its unique membrane-bound receptor IL-6R and gp130.
Interleukin-6 Binding (bound) of gp130 associated with cytokine
2) Confidence 0.21 Published 2005 Journal Cytokine Section Abstract Doc Link 15863388 Disease Relevance 0.39 Pain Relevance 0.35
IL-6 can bind to a membrane-bound IL-6 receptor (IL-6R) which acts in cooperation with the transmembrane signal-transducing subunit soluble glycoprotein 130 (gp130) [4,5].
IL-6 Binding (bind) of gp130
3) Confidence 0.08 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945031 Disease Relevance 0.83 Pain Relevance 0.43
While sIL-6R acts as an agonist, circulating soluble gp130 (sgp130) acts as an antagonist, because it binds IL-6/sIL-6R complexes and thus prevents transsignalling [4,5].
IL-6 Binding (binds) of gp130 associated with antagonist and agonist
4) Confidence 0.08 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945031 Disease Relevance 0.91 Pain Relevance 0.65
Alternatively, IL-6 can bind to a soluble IL-6 receptor (sIL-6R), and the IL-6/sIL-6R complex can bind to the transmembrane signal-transducing subunit gp130 of cells which do not express the membrane-bound IL-6R, thus leading to IL-6 transsignalling [5].
IL-6 Binding (bind) of gp130
5) Confidence 0.07 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945031 Disease Relevance 0.83 Pain Relevance 0.45

General Comments

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