INT127056

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Context Info
Confidence 0.10
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.06
Pain Relevance 0.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Ddc) plasma membrane (Drd3) intracellular (Ddc)
signal transducer activity (Drd3) cellular amino acid metabolic process (Ddc) cytoplasm (Ddc)
Anatomy Link Frequency
striatum 2
Ddc (Rattus norvegicus)
Drd3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 2 100.00 Very High Very High Very High
Glutamate 1 100.00 Very High Very High Very High
Dynorphin 4 95.84 Very High Very High Very High
Enkephalin 4 83.40 Quite High
antagonist 1 69.48 Quite High
dopamine receptor 1 61.16 Quite High
Thalamus 1 51.04 Quite High
Disease Link Frequency Relevance Heat
Disease 1 56.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
L-DOPA treatment increased dopamine D3 receptor and glutamate transporter 1 (GLT1) mRNA expression in the lesioned striatum and that, specifically in an area overlapping one of Nur77 decrease and of NT/DYN induction.
L-DOPA Positive_regulation (increased) of Transcription (expression) of dopamine D3 receptor in striatum associated with glutamate, dopamine and dynorphin
1) Confidence 0.10 Published 2005 Journal Neurobiol. Dis. Section Abstract Doc Link 15896973 Disease Relevance 0.06 Pain Relevance 0.63

General Comments

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