INT127176

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Context Info
Confidence 0.58
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 4.68
Pain Relevance 2.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Ptgs2) oxidoreductase activity (Ptgs2) endoplasmic reticulum (Ptgs2)
nucleus (Ptgs2) enzyme binding (Ptgs2) protein complex (Ptgs2)
Anatomy Link Frequency
macrophages 2
Ptgs2 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 35 100.00 Very High Very High Very High
COX2 8 100.00 Very High Very High Very High
Thermal hyperalgesia 2 99.64 Very High Very High Very High
cytokine 3 94.32 High High
Antinociceptive 2 93.72 High High
Pain 4 92.88 High High
cINOD 16 92.56 High High
COX-2 inhibitor 3 90.52 High High
Spinal cord 4 88.56 High High
Inflammatory mediators 2 87.84 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 39 100.00 Very High Very High Very High
Necrosis 5 100.00 Very High Very High Very High
Cancer 5 100.00 Very High Very High Very High
Hyperalgesia 3 99.64 Very High Very High Very High
Infection 1 98.40 Very High Very High Very High
Sepsis 1 94.72 High High
Fever 1 93.28 High High
Pain 5 92.88 High High
Encephalitis 1 92.00 High High
Inflammatory Pain 5 86.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SA was not expected to have any effect in this assay because it is known not to affect PGHS-1 or 2 activity [31] except in intact cells [30], possibly by suppressing PGHS-2 transcription in response to exogenous stimuli [32].
Transcription (transcription) of PGHS-2
1) Confidence 0.58 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1592475 Disease Relevance 0 Pain Relevance 0.08
Cyclooxygenase-2 gene transcription in a macrophage model of inflammation.
Transcription (transcription) of Cyclooxygenase-2 in macrophage associated with inflammation and cox2
2) Confidence 0.37 Published 2006 Journal J. Immunol. Section Title Doc Link 17114486 Disease Relevance 0.62 Pain Relevance 0.38
The primary regulator of PG synthesis is the mRNA expression of PG H Synthase (PGHS-2 or COX-2).
Transcription (expression) of PGHS-2
3) Confidence 0.35 Published 2007 Journal Front. Biosci. Section Abstract Doc Link 17127385 Disease Relevance 0.17 Pain Relevance 0.16
Role of interleukin-1beta and tumor necrosis factor-alpha-dependent expression of cyclooxygenase-2 mRNA in thermal hyperalgesia induced by chronic inflammation in mice.
Transcription (expression) of cyclooxygenase-2 associated with necrosis, inflammation, cancer, thermal hyperalgesia and cox2
4) Confidence 0.32 Published 2008 Journal Neuroscience Section Title Doc Link 18262365 Disease Relevance 0.84 Pain Relevance 0.83
ME10092 dose-dependently inhibited LPS-induced nuclear translocation of NF-kappaB, transcription of tumour necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2).
Transcription (transcription) of cyclooxygenase-2 associated with necrosis and cancer
5) Confidence 0.26 Published 2010 Journal Int. Immunopharmacol. Section Abstract Doc Link 20074673 Disease Relevance 0.53 Pain Relevance 0.24
Consistent with these observations, MEIO potently inhibited the protein and mRNA expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2).
Transcription (expressions) of cyclooxygenase-2
6) Confidence 0.16 Published 2005 Journal J Ethnopharmacol Section Abstract Doc Link 15905055 Disease Relevance 0.98 Pain Relevance 0.23
For example, 15d-PGJ2 represses the transcription of a number of pro-inflammatory factors including inducible nitric oxide synthase, cyclooxygenase-2 and tumor necrosis factor-?
Transcription (transcription) of cyclooxygenase-2 associated with necrosis, inflammation and cancer
7) Confidence 0.15 Published 2008 Journal Mol Pain Section Body Doc Link PMC2515828 Disease Relevance 1.11 Pain Relevance 0.38
Coordinated up-regulation of cyclooxygenase-2 and microsomal prostaglandin E synthase 1 transcription by nuclear factor kappa B and early growth response-1 in macrophages.
Transcription (transcription) of cyclooxygenase-2 in macrophages associated with cox2
8) Confidence 0.11 Published 2010 Journal Cell. Signal. Section Title Doc Link 20546888 Disease Relevance 0.43 Pain Relevance 0.28

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