INT127323

Context Info Confidence 0.69 First Reported 2005 Last Reported 2009 Negated 1 Speculated 1 Reported most in Abstract Documents 8 Total Number 9 Disease Relevance 0.96 Pain Relevance 1.42

transmembrane transport (Trpa1)

Trpa1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat agonist 18 99.98 Pain 13 95.32 TRP channel 30 93.24 addiction 2 78.96 Inflammation 2 75.56 Hyperalgesia 6 74.16 Potency 5 65.92 Root ganglion neuron 23 30.56 alcohol 6 22.52 qutenza 25 5.00

Disease Link Frequency Relevance Heat Pain 6 94.88 Neurogenic Inflammation 1 75.56 Stress 6 75.00 Hyperalgesia 6 74.16 Ganglion Cysts 28 50.00 Loss Of Sense Of Smell 2 5.00 Neuropathic Pain 2 5.00 Pruritus 2 5.00 Bites And Stings 1 5.00 Tick Infestations 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We conclude that, via generation of reactive oxygen species, light-induced TRPA1 activation provides an additional mode of activation, which renders TRPA1 a likely molecular candidate in processes leading to painful or burning sensations during photodynamic therapy or upon local application of hydrogen peroxide.

Positive_regulation (induced) of Positive_regulation (activation) of TRPA1 associated with pain

1) Confidence 0.69 Published 2009 Journal Cell Calcium Section Abstract Doc Link 18814910 Disease Relevance 0.07 Pain Relevance 0.10

In the presence of the photosensitising agents acridine orange (100 nM) or hypericin (10 nM), the sensitivity of light-induced TRPA1 activation was increased and extended towards the visible spectrum.

Positive_regulation (induced) of Positive_regulation (activation) of TRPA1

2) Confidence 0.69 Published 2009 Journal Cell Calcium Section Abstract Doc Link 18814910 Disease Relevance 0.15 Pain Relevance 0.07

Since extracellular application of hydrogen peroxide mimicked the effect of UVA irradiation and since dithiothreitol partly reversed the activation by UVA exposure, we conclude that reactive oxygen species may mediate the light-induced activation of TRPA1.

Spec (may) Positive_regulation (mediate) of Positive_regulation (activation) of TRPA1

3) Confidence 0.69 Published 2009 Journal Cell Calcium Section Abstract Doc Link 18814910 Disease Relevance 0.14 Pain Relevance 0.12

Intracellular but not extracellular application of FeSO(4), which catalyses the formation of highly reactive hydroxyl radicals potentiated the hydrogen peroxide-stimulated TRPA1 activation.

Positive_regulation (stimulated) of Positive_regulation (activation) of TRPA1

4) Confidence 0.50 Published 2009 Journal Cell Calcium Section Abstract Doc Link 18814910 Disease Relevance 0.07 Pain Relevance 0.08

Accordingly, hydrogen peroxide induced a TRPA1 activation with a membrane-delimited mode of action that was attenuated by dithiothreitol.

Positive_regulation (induced) of Positive_regulation (activation) of TRPA1

5) Confidence 0.47 Published 2009 Journal Cell Calcium Section Abstract Doc Link 18814910 Disease Relevance 0.13 Pain Relevance 0.12

In the presence of the photosensitising agents acridine orange (100 nM) or hypericin (10 nM), the sensitivity of light-induced TRPA1 activation was increased and extended towards the visible spectrum.

Positive_regulation (increased) of Positive_regulation (activation) of TRPA1

6) Confidence 0.47 Published 2009 Journal Cell Calcium Section Abstract Doc Link 18814910 Disease Relevance 0.15 Pain Relevance 0.07

Here, we report that electrophilic, thioaminal-containing compounds [e.g., CMP1 (4-methyl-N-[2,2,2-trichloro-1-(4-nitro-phenylsulfanyl)-ethyl]-benzamide)] covalently modify cysteine residues but produce striking species-specific effects [i.e., activation of rat TRPA1 (rTRPA1) and blockade of human TRPA1 (hTRPA1) activation by reactive and nonreactive agonists].

Positive_regulation (activation) of Positive_regulation (activation) of TRPA1 associated with agonist

7) Confidence 0.46 Published 2008 Journal J. Neurosci. Section Abstract Doc Link 18463259 Disease Relevance 0.15 Pain Relevance 0.16

In contrast, agonist activation of TRPM8, TRPV4, and TRPA1 was not increased or potentiated by citral (Fig. 2D, E).

Neg (not) Positive_regulation (increased) of Positive_regulation (activation) of TRPA1 associated with agonist

8) Confidence 0.31 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346451 Disease Relevance 0 Pain Relevance 0.51

We further show that allicin, an unstable component of fresh garlic, is the chemical responsible for TRPA1 and TRPV1 activation and is therefore likely to cause garlic's pungency.

Positive_regulation (responsible) of Positive_regulation (activation) of TRPA1

9) Confidence 0.30 Published 2005 Journal Curr. Biol. Section Abstract Doc Link 15916949 Disease Relevance 0.09 Pain Relevance 0.18

General Comments

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