INT127435

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Context Info
Confidence 0.77
First Reported 2004
Last Reported 2010
Negated 4
Speculated 2
Reported most in Body
Documents 89
Total Number 93
Disease Relevance 13.94
Pain Relevance 22.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Per1) nucleus (Per1) protein binding transcription factor activity (Per1)
cytoplasm (Per1) signal transducer activity (Per1)
Anatomy Link Frequency
brain 13
neurons 4
kidney 3
nucleus accumbens 3
lungs 2
Per1 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 191 99.92 Very High Very High Very High
Hippocampus 71 99.84 Very High Very High Very High
cocaine 46 99.72 Very High Very High Very High
withdrawal 837 99.58 Very High Very High Very High
gABA 260 99.56 Very High Very High Very High
Morphine 1174 99.52 Very High Very High Very High
Glutamate 67 99.46 Very High Very High Very High
Dopamine 159 99.38 Very High Very High Very High
tetrodotoxin 74 99.32 Very High Very High Very High
dorsal root ganglion 55 99.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 249 99.88 Very High Very High Very High
Neurodegenerative Disease 25 99.60 Very High Very High Very High
Diabetes Mellitus 283 99.50 Very High Very High Very High
Convulsion 53 99.40 Very High Very High Very High
Lipodystrophy 12 99.36 Very High Very High Very High
Ganglion Cysts 182 99.08 Very High Very High Very High
Obesity 86 99.08 Very High Very High Very High
Prostate Cancer 56 98.80 Very High Very High Very High
Morphine Dependence 144 98.64 Very High Very High Very High
Hyperinsulinism 36 97.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, the phase of the circadian rhythm of mPer1 expression was advanced in mice of the MD group compared with the Con and MW groups (Figure 2a).
Gene_expression (expression) of mPer1 associated with withdrawal
1) Confidence 0.77 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1563481 Disease Relevance 0 Pain Relevance 0.48
Rhythmic expression of mPER1 was analyzed according to the mPER1 expression data determined by image pro plus software and shown in Figure 4 and Table 1.
Gene_expression (expression) of mPER1
2) Confidence 0.77 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1563481 Disease Relevance 0 Pain Relevance 0.31
Altered expression of circadian clock gene, mPer1, in mouse brain and kidney under morphine dependence and withdrawal

Every physiological function in the human body exhibits some form of circadian rhythmicity.

Gene_expression (expression) of mPer1 in brain associated with addiction, withdrawal and morphine
3) Confidence 0.77 Published 2006 Journal J Circadian Rhythms Section Title Doc Link PMC1563481 Disease Relevance 0.28 Pain Relevance 0.53
Under high power (200×) and viewed with inverted microscope (Nikon TE 2000-U), mPER1 protein expression in the brains and kidneys were clearly observed.
Gene_expression (expression) of mPER1 protein in brains
4) Confidence 0.77 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1563481 Disease Relevance 0 Pain Relevance 0.33
In contrast, there were weak expressions of mPER1 in the kidneys of the MD and MW mice.


Gene_expression (expressions) of mPER1 associated with withdrawal
5) Confidence 0.77 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1563481 Disease Relevance 0 Pain Relevance 0.43
Thus, we sought to investigate whether morphine treatment could alter the expression of mPer1, especially in brain regions outside the SCN and in peripheral tissues.
Gene_expression (expression) of mPer1 in brain associated with morphine
6) Confidence 0.77 Published 2006 Journal J Circadian Rhythms Section Abstract Doc Link PMC1563481 Disease Relevance 0.24 Pain Relevance 0.64
In the brain, morphine increases the level of mPER1 expression and advances the phase of the circadian rhythm.
Gene_expression (expression) of mPER1 in brain associated with morphine
7) Confidence 0.77 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1563481 Disease Relevance 0.33 Pain Relevance 0.37
Circadian rhythmicity of mPER1 expression persisted after morphine administration, but the circadian pattern of mPER1 expression in the brains was changed: the MESOR was elevated and the acrophase (peak time) was shifted ahead in MD mice as compated to Con and MW mice.
Gene_expression (expression) of mPER1 in brains associated with withdrawal and morphine
8) Confidence 0.77 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1563481 Disease Relevance 0 Pain Relevance 0.40
Western blot test showed that the mPER1 protein, which reflects mPer1 gene expression, exhibited robust circadian rhythmicity in whole brain.
Gene_expression (expression) of mPer1 in brain
9) Confidence 0.77 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1563481 Disease Relevance 0 Pain Relevance 0.51
Circadian rhythmicity of mPER1 expression persisted after morphine administration, but the circadian pattern of mPER1 expression in the brains was changed: the MESOR was elevated and the acrophase (peak time) was shifted ahead in MD mice as compated to Con and MW mice.
Gene_expression (expression) of mPER1 in brains associated with withdrawal and morphine
10) Confidence 0.77 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1563481 Disease Relevance 0 Pain Relevance 0.37
In contrast to mPER1 expression in the brain, the circadian rhythm of mPER1 immunoreactivity in the kidneys was abolished after morphine administration, whereas the Con mice maintained robust circadian rhythmicity of mPER1 in the kidney.
Gene_expression (expression) of mPER1 in kidney associated with morphine
11) Confidence 0.77 Published 2006 Journal J Circadian Rhythms Section Abstract Doc Link PMC1563481 Disease Relevance 0.20 Pain Relevance 0.75
Using immunohistochemistry and image analysis for expression of mPER1 protein, we found that the expression of mPER1 protein in the piriform cortex, nucleus accumbens and gyrus dentatus of the hippocampus fluctuated throughout the 12L:12D cycle (Figure 4a, Table 1).
Gene_expression (expression) of mPER1 protein in piriform cortex associated with nucleus accumbens and hippocampus
12) Confidence 0.77 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1563481 Disease Relevance 0 Pain Relevance 0.34
The acrophase of mPER1 expression did not differ significantly between the Con group (22:54) and the MW group (23:24).
Gene_expression (expression) of mPER1 associated with withdrawal
13) Confidence 0.77 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1563481 Disease Relevance 0 Pain Relevance 0.43
In Con and MW mice, high level of mPER1 protein expression in brains was observed at 0:00.
Gene_expression (expression) of mPER1 protein in brains associated with withdrawal
14) Confidence 0.77 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1563481 Disease Relevance 0 Pain Relevance 0.50
However, the phase of the circadian rhythm of mPER1 expression in the brains of MD mice significantly differed from that of the Con mice (p < 0.05).
Gene_expression (expression) of mPER1 in brains
15) Confidence 0.77 Published 2006 Journal J Circadian Rhythms Section Abstract Doc Link PMC1563481 Disease Relevance 0.21 Pain Relevance 0.75
High expression of mPER1 is seen as brown-yellow, whereas low expression is seen as blue in the sections (Figure 3).
Gene_expression (expression) of mPER1
16) Confidence 0.77 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1563481 Disease Relevance 0 Pain Relevance 0.38
The mPER1 protein expression level in MD mice was increased between 8:00 and 20:00.
Gene_expression (expression) of mPER1 protein
17) Confidence 0.77 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1563481 Disease Relevance 0 Pain Relevance 0.51
Using immunohistochemistry and image analysis for expression of mPER1 protein, we found that the expression of mPER1 protein in the piriform cortex, nucleus accumbens and gyrus dentatus of the hippocampus fluctuated throughout the 12L:12D cycle (Figure 4a, Table 1).
Gene_expression (expression) of mPER1 protein in piriform cortex associated with nucleus accumbens and hippocampus
18) Confidence 0.77 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1563481 Disease Relevance 0 Pain Relevance 0.35
In the kidney, morphine decreases the level of mPER1 expression and abolishes circadian rhythmicity.


Gene_expression (expression) of mPER1 in kidney associated with morphine
19) Confidence 0.77 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1563481 Disease Relevance 0.21 Pain Relevance 0.29
Our results showed that the expression of mPER1 in the kidneys was higher at night in the control mice, coinciding with the peak activity of potassium excretion [27].
Gene_expression (expression) of mPER1
20) Confidence 0.77 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1563481 Disease Relevance 0.60 Pain Relevance 0.47

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