INT127662

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Context Info
Confidence 0.15
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.75
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (PDE4A, PTGS2) nucleus (PDE4A, PTGS2) small molecule metabolic process (PTGS2)
endoplasmic reticulum (PTGS2) enzyme binding (PTGS2) protein complex (PTGS2)
PDE4A (Homo sapiens)
PTGS2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 3 99.68 Very High Very High Very High
Inflammation 2 99.32 Very High Very High Very High
Inflammatory response 3 80.32 Quite High
metalloproteinase 2 75.00 Quite High
Dismenorea 1 69.88 Quite High
COX2 1 25.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 5 99.32 Very High Very High Very High
Rupture 2 96.80 Very High Very High Very High
Dysmenorrhea 1 69.88 Quite High
Bacterial Infection 1 62.56 Quite High
Premature Rupture Fetal Membranes 1 60.88 Quite High
Infection 3 58.20 Quite High
Premature Birth 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PDE4 inhibition reduced cyclooxygenase-2 protein expression and PGE(2) production and also modulated MMP-9, a key mediator of the membrane rupture process, by inhibiting pro-MMP-9 mRNA expression and pro-MMP-9 activity.
Negative_regulation (inhibition) of PDE4 Negative_regulation (reduced) of Gene_expression (expression) of cyclooxygenase-2 protein associated with rupture
1) Confidence 0.15 Published 2005 Journal J. Immunol. Section Abstract Doc Link 15944316 Disease Relevance 0.75 Pain Relevance 0.47

General Comments

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