INT127667

From wiki-pain
Revision as of 14:24, 22 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.59
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 8
Disease Relevance 5.89
Pain Relevance 4.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CXCL10) extracellular space (CXCL10) extracellular region (CXCL10)
cell-cell signaling (CXCL10)
Anatomy Link Frequency
monocytes 6
myoblasts 2
fibroblasts 2
CXCL10 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 132 100.00 Very High Very High Very High
Inflammation 34 100.00 Very High Very High Very High
Fibrositis 13 99.84 Very High Very High Very High
chemokine 228 96.96 Very High Very High Very High
Arthritis 13 80.88 Quite High
pulpitis 2 79.72 Quite High
Inflammatory response 3 77.80 Quite High
metalloproteinase 2 75.00 Quite High
rheumatoid arthritis 30 73.28 Quite High
Dismenorea 1 72.40 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 37 100.00 Very High Very High Very High
Fibromyalgia 10 99.84 Very High Very High Very High
Infection 36 91.44 High High
Hepatitis C Virus Infection 84 91.04 High High
Cryoglobulinemia 146 88.92 High High
Rupture 2 88.72 High High
Diabetes Mellitus 3 86.80 High High
Arthritis 19 80.88 Quite High
Pulpitis 2 79.72 Quite High
Cancer 7 73.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, heat-killed bacteria did not induce CXCL10 secretion.
Neg (not) Positive_regulation (induce) of Localization (secretion) of CXCL10
1) Confidence 0.59 Published 2007 Journal J. Dent. Res. Section Abstract Doc Link 18037659 Disease Relevance 0.46 Pain Relevance 0.51
may in turn induce CXCL10 secretion by infected cells, thus perpetuating the immune cascade responsible for these endocrine disorders.
Positive_regulation (induce) of Localization (secretion) of CXCL10
2) Confidence 0.32 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2569912 Disease Relevance 1.43 Pain Relevance 0
Interferon-gamma inducible protein-10 (IP-10)/CXCL10 (a ligand of CXCR3) is expressed and secreted by monocytes and fibroblasts following stimulation with IFN-?
Positive_regulation (following) of Localization (secreted) of IP-10 in monocytes
3) Confidence 0.32 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896663 Disease Relevance 0.52 Pain Relevance 0.59
Interferon-gamma inducible protein-10 (IP-10)/CXCL10 (a ligand of CXCR3) is expressed and secreted by monocytes and fibroblasts following stimulation with IFN-?
Positive_regulation (following) of Localization (secreted) of CXCL10 in monocytes
4) Confidence 0.32 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896663 Disease Relevance 0.52 Pain Relevance 0.59
Furthermore, myoblasts can secrete MCP-1, eotaxin, and IP-10, while treatment with MCP-1 caused secretion of IL-1beta, eotaxin and IP-10.
Positive_regulation (caused) of Localization (secretion) of IP-10 in myoblasts
5) Confidence 0.19 Published 2008 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 18535166 Disease Relevance 1.16 Pain Relevance 0.73
Interferon-gamma inducible protein-10 (IP-10)/CXCL10 (a ligand of CXCR3) is expressed and secreted by monocytes and fibroblasts following stimulation with IFN-?
Positive_regulation (following) of in fibroblasts Localization (secreted) of CXCL10 in monocytes
6) Confidence 0.11 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896663 Disease Relevance 0.52 Pain Relevance 0.59
Interferon-gamma inducible protein-10 (IP-10)/CXCL10 (a ligand of CXCR3) is expressed and secreted by monocytes and fibroblasts following stimulation with IFN-?
Positive_regulation (following) of in fibroblasts Localization (secreted) of IP-10 in monocytes
7) Confidence 0.11 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896663 Disease Relevance 0.52 Pain Relevance 0.59
Selective inhibition of PDE4 activity affected LPS signaling, because PDE4 inhibitors (rolipram and/or cilomilast) reduced the release of the proinflammatory cytokine TNF-alpha and increased the release of the anti-inflammatory cytokine IL-10.
Positive_regulation (increased) of Localization (release) of cytokine IL-10 associated with inflammation and cytokine
8) Confidence 0.08 Published 2005 Journal J. Immunol. Section Abstract Doc Link 15944316 Disease Relevance 0.75 Pain Relevance 0.48

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox