INT12786

Context Info Confidence 0.10 First Reported 1991 Last Reported 2008 Negated 4 Speculated 0 Reported most in Body Documents 14 Total Number 14 Disease Relevance 2.03 Pain Relevance 0.55

Anatomy Link Frequency nucleus 1 Srv (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 240 96.28 anesthesia 5 93.16 nociceptor 1 25.00 ketamine 13 5.00 lidocaine 12 5.00 Pain 2 5.00 Perioperative pain 1 5.00 Buprenorphine 1 5.00 analgesia 1 5.00 Visceral pain 1 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 240 96.28 Eosinophilia 96 96.12 Hypersensitivity 168 95.08 Pressure Volume 2 Under Development 1 87.08 Nociception 3 86.72 Pneumoperitoneum 22 74.40 Asthma 24 56.52 Acidosis 7 33.36 Disease 26 5.00 Rhinitis 24 5.00

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Mutation

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Anatomy

Negation

Speculation

Pain term

Disease term

While increased maximal responses can be seen in both airway and parenchymal compartments, depending on which model is used, no increase in parenchymal sensitivity is seen with any of the models we used.

Neg (no) Positive_regulation (increase) of sensitivity

1) Confidence 0.10 Published 2004 Journal Respir Res Section Body Doc Link PMC521690 Disease Relevance 0.15 Pain Relevance 0

Increased maximal responses, but not increased sensitivity, were also seen in the parenchymal compartment at both the 24 and 48 hour time points.

Neg (not) Positive_regulation (increased) of sensitivity

2) Confidence 0.10 Published 2004 Journal Respir Res Section Body Doc Link PMC521690 Disease Relevance 0.09 Pain Relevance 0.05

Sensitisation followed by challenge with a single PBS aerosol did not cause an increase in sensitivity or maximum responsiveness to MCh compared to naïve mice.

Positive_regulation (increase) of sensitivity

3) Confidence 0.10 Published 2004 Journal Respir Res Section Body Doc Link PMC521690 Disease Relevance 0 Pain Relevance 0

Six OVA aerosols resulted in both significantly increased airway sensitivity and maximal responses to MCh at 24 and 48 hours post-challenge.

Positive_regulation (increased) of sensitivity

4) Confidence 0.10 Published 2004 Journal Respir Res Section Body Doc Link PMC521690 Disease Relevance 0.08 Pain Relevance 0.04

In the parenchymal compartment, no increase in sensitivity was seen but a significant increase in maximal response was seen for both G and H.

Neg (no) Positive_regulation (increase) of sensitivity

5) Confidence 0.10 Published 2004 Journal Respir Res Section Body Doc Link PMC521690 Disease Relevance 0 Pain Relevance 0

A single OVA aerosol was sufficient to induce a significant increase in MCh responsiveness in the airways, seen as both a lower threshold dose of MCh required to induce a response (increased sensitivity) and increased response at the 24 hour time point (Table 1).

Positive_regulation (increased) of sensitivity

6) Confidence 0.10 Published 2004 Journal Respir Res Section Body Doc Link PMC521690 Disease Relevance 0 Pain Relevance 0

Three OVA aerosols resulted in significantly increased airway (but not parenchymal) sensitivity to MCh at both the 24 and 48 hour time points (Table 1).

Positive_regulation (increased) of sensitivity

7) Confidence 0.08 Published 2004 Journal Respir Res Section Body Doc Link PMC521690 Disease Relevance 0.06 Pain Relevance 0.03

About half of the SRV units tested were antidromically activated by electrical stimulation of the nucleus centralis lateralis.

Positive_regulation (activated) of SRV in nucleus

8) Confidence 0.07 Published 1991 Journal Neurosci. Res. Section Abstract Doc Link 1653919 Disease Relevance 0.16 Pain Relevance 0

The threshold dose of MCh required to elicit a detectable response (sensitivity) and response to 30 mg.mL-1 (maximal response) were determined for each compartment.

Positive_regulation (elicit) of sensitivity

9) Confidence 0.07 Published 2004 Journal Respir Res Section Abstract Doc Link PMC521690 Disease Relevance 0.22 Pain Relevance 0.05

A single OVA challenge increased airway sensitivity to inhaled MCh 24 hours after the challenge, while sensitivity remained elevated for 48 hours after three and six challenges.

Positive_regulation (increased) of sensitivity

10) Confidence 0.07 Published 2004 Journal Respir Res Section Body Doc Link PMC521690 Disease Relevance 0.19 Pain Relevance 0.05

Sensitivity; All three OVA protocols resulted in an increased sensitivity to MCh in Raw but not in G or H.

Positive_regulation (increased) of sensitivity

11) Confidence 0.07 Published 2004 Journal Respir Res Section Abstract Doc Link PMC521690 Disease Relevance 0.28 Pain Relevance 0.04

In this study, increased sensitivity to MCh was confined to the airways whereas increases in maximal responses occurred in both the airway and parenchymal compartments.

Positive_regulation (increased) of sensitivity

12) Confidence 0.07 Published 2004 Journal Respir Res Section Abstract Doc Link PMC521690 Disease Relevance 0.33 Pain Relevance 0.03

OVA challenge did not increase parenchymal sensitivity at any level.

Neg (not) Positive_regulation (increase) of sensitivity

13) Confidence 0.07 Published 2004 Journal Respir Res Section Body Doc Link PMC521690 Disease Relevance 0.29 Pain Relevance 0.10

Immediate and significant increases in ABP and SRV

Positive_regulation (increases) of SRV

14) Confidence 0.04 Published 2008 Journal Anesthesiology Research and Practice Section Body Doc Link PMC3003954 Disease Relevance 0.16 Pain Relevance 0.16

General Comments

This test has worked.