INT128151

Context Info Confidence 0.24 First Reported 2005 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 3 Total Number 3 Disease Relevance 2.00 Pain Relevance 1.11

extracellular region (Reg3a)

Anatomy Link Frequency Acinar cell 2 Reg3a (Rattus norvegicus)

Pain Link Frequency Relevance Heat Chronic pancreatitis 10 100.00 Inflammation 13 99.84 alcohol 2 99.60 fibrosis 4 92.16 abdominal pain 1 83.28 Pain 5 38.16 palliative 1 25.00 Analgesic 1 25.00

Disease Link Frequency Relevance Heat Pancreatitis 13 100.00 INFLAMMATION 13 99.84 Fibrosis 5 92.16 Abdominal Pain 1 83.28 Pancreatic Cancer 4 75.00 Alcohol Addiction 1 71.52 Alcoholic Pancreatitis 2 62.16 Nicotine Addiction 2 50.00 Pain 4 38.16 Steatorrhea 1 26.48

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Acinar cell stress was manifested by a significant up-regulation of pancreatitis-associated protein expression (PAP) in smoke-exposed animals (smoke-exposed 6,932 +/- 1,236 vs control 3,608 +/- 305, p < 0.05).

Positive_regulation (up-regulation) of pancreatitis-associated protein in Acinar cell

1) Confidence 0.24 Published 2006 Journal Am. J. Gastroenterol. Section Body Doc Link 16405548 Disease Relevance 0 Pain Relevance 0

Proteins produced by acinar cells and characteristic for inflammation, e.g., pancreatitis-associated protein, are highly upregulated.

Positive_regulation (upregulated) of pancreatitis-associated protein in acinar cells associated with inflammation and pancreatitis

2) Confidence 0.09 Published 2009 Journal Physiol. Genomics Section Abstract Doc Link 19435834 Disease Relevance 1.42 Pain Relevance 0.76

Chronic pancreatitis is mostly caused by heavy alcohol consumption and is characterized by the onset of symptoms in the fourth and fifth decade.

Positive_regulation (caused) of pancreatitis associated with chronic pancreatitis and alcohol

3) Confidence 0.01 Published 2005 Journal Praxis Section Abstract Doc Link 15986640 Disease Relevance 0.59 Pain Relevance 0.35

General Comments

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