INT128179

From wiki-pain
Revision as of 20:20, 23 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.64
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 34
Disease Relevance 2.48
Pain Relevance 3.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (RHOA) mitochondrion (RHOA) cell morphogenesis (RHOA)
intracellular (RHOA) GTPase activity (RHOA) cytoplasm (RHOA)
Anatomy Link Frequency
platelets 2
neuronal 1
vasculature 1
band 1
nucleus 1
RHOA (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 447 99.76 Very High Very High Very High
cytokine 39 99.44 Very High Very High Very High
Morphine 14 98.92 Very High Very High Very High
Inflammation 147 93.92 High High
Opioid 3 89.28 High High
addiction 1 88.92 High High
tolerance 4 88.32 High High
mu opioid receptor 5 86.76 High High
bradykinin 9 85.48 High High
opiate 1 75.00 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 118 98.96 Very High Very High Very High
Asthma 117 98.64 Very High Very High Very High
Pulmonary Disease 153 98.20 Very High Very High Very High
Hypersensitivity 12 97.72 Very High Very High Very High
Disease 114 94.52 High High
INFLAMMATION 176 93.92 High High
Leukemia 30 91.40 High High
Stress 87 85.92 High High
Atherosclerosis 128 60.36 Quite High
Hypertension 115 58.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, MNTX or silencing RhoA expression (siRNA) blocked MS, DAMGO and VEGF-induced EC proliferation and migration.
Gene_expression (expression) of RhoA
1) Confidence 0.64 Published 2006 Journal Microvasc. Res. Section Abstract Doc Link 16820176 Disease Relevance 0 Pain Relevance 0.63
In parallel, to confirm equivalent RhoA protein expression in the cell lysates and uniform protein loading, aliquots of whole cell lysates (typically 10 ?
Gene_expression (expression) of RhoA
2) Confidence 0.55 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.04
-mediated RhoA signaling in primary human AoSMCs
Gene_expression (signaling) of RhoA
3) Confidence 0.48 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.04
independently regulated RhoA activation and signaling in clonal cells over-expressing TP?
Gene_expression (activation) of RhoA
4) Confidence 0.48 Published 2008 Journal Cellular Signalling Section Abstract Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
expression and RhoA-mediated signaling in their respective HEK 293 cell lines.
Gene_expression (expression) of RhoA
5) Confidence 0.48 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.10 Pain Relevance 0
independently contribute to U46619-induced RhoA activation and signaling in 1° h.AoSMCs and to ascertain whether the inhibitory effects of NO and/or Cicaprost may directly target TP?
Gene_expression (activation) of RhoA
6) Confidence 0.48 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.07 Pain Relevance 0.06
Moreover, in a recent study investigating NGF-mediated RhoA responses in neuronal PC12 cells, Nusser et al. provided in vitro and in vivo evidence to suggest that Ser188 phosphorylation of RhoA impairs activation of Rho kinase (ROCK 1/2), but does not affect its ability to activate other Rho effectors including rhotekin, mDia-1 and PKN [47].
Gene_expression (responses) of RhoA in neuronal
7) Confidence 0.48 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
In general, GPCR-mediated RhoA activation largely occurs through a G12, mainly G?
Gene_expression (activation) of RhoA
8) Confidence 0.48 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.08 Pain Relevance 0.05
13/RhoGEF-RhoA activation and are in agreement with a host of studies in mouse platelets whereby the single TP in that species couples to Gq/PLC?
Gene_expression (activation) of RhoA in platelets
9) Confidence 0.48 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.08 Pain Relevance 0.04
independently or indeed differentially modulate RhoA activation and downstream signaling, there is substantial evidence that the TP?
Gene_expression (activation) of RhoA
10) Confidence 0.48 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.18 Pain Relevance 0.04
Hence, herein, we sought to clarify the involvement of G12 and Gq on TP-mediated RhoA signaling and found that dominant negative forms of G?
Gene_expression (signaling) of RhoA
11) Confidence 0.48 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.09 Pain Relevance 0.04
-mediated RhoA signalling, both NO and prostacyclin directly target RhoA phosphorylation at Ser188 through their regulation of PKG and PKA signaling, respectively (data not shown).
Gene_expression (signalling) of RhoA
12) Confidence 0.48 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
Moreover, in keeping with that hypothesis, the finding that agonist-induced G12/RhoA signaling by TP?
Gene_expression (signaling) of RhoA associated with agonist
13) Confidence 0.48 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.05
In the event that the ‘phospho-RhoASer188 switch mechanism’ exists within TXA2-responsive VSM or indeed in platelets, RhoA signaling through TP?
Gene_expression (signaling) of RhoA in platelets
14) Confidence 0.48 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
qQ209 l,D277N), significantly impaired U46619-mediated RhoA activation through both TP?
Gene_expression (activation) of RhoA
15) Confidence 0.48 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.14 Pain Relevance 0
qQ209l,D277N), significantly impaired U46619-mediated RhoA activation and cofilin phosphorylation.
Gene_expression (activation) of RhoA
16) Confidence 0.48 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.09 Pain Relevance 0.04
Having established the specificity of the siRNA reagents to impair expression and RhoA-dependent signaling by both TP?
Gene_expression (expression) of RhoA
17) Confidence 0.48 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
to mediate RhoA signaling in established clonal HEK 293 cell lines that over-express the individual TP isoforms [20,21] and in cultured 1° AoSMCs, a physiologically relevant cell type that expresses both TP?
Gene_expression (signaling) of RhoA
18) Confidence 0.48 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.23 Pain Relevance 0
On the other hand, the inhibitory effect of SIN-1 on U46619-mediated RhoA activation in 1° h.AoSMCs was significantly less in the presence of siRNATP?
Gene_expression (activation) of RhoA
19) Confidence 0.48 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
significantly impaired U46619-induced RhoA activation but had no significant effect on such signaling in HEK.TP?
Gene_expression (activation) of RhoA
20) Confidence 0.48 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0.21 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox