INT12843

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Context Info
Confidence 0.60
First Reported 1987
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 13
Total Number 17
Disease Relevance 3.46
Pain Relevance 3.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Pck1) nucleolus (Pck1) nucleus (Pck1)
lipid metabolic process (Pck1) cytoplasm (Pck1)
Anatomy Link Frequency
hepatocytes 2
brain 2
bile 2
liver 1
external 1
Pck1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 37 100.00 Very High Very High Very High
mu opioid receptor 2 100.00 Very High Very High Very High
Enkephalin 4 99.72 Very High Very High Very High
Bile 306 99.42 Very High Very High Very High
opioid receptor 3 99.34 Very High Very High Very High
MU agonist 2 98.02 Very High Very High Very High
Clonidine 3 94.76 High High
Potency 3 92.12 High High
agonist 48 90.84 High High
antagonist 23 88.20 High High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 119 99.28 Very High Very High Very High
Fistula 95 98.64 Very High Very High Very High
Bordatella Infection 28 93.84 High High
Body Weight 2 78.96 Quite High
Stress 2 59.12 Quite High
Toxicity 8 49.12 Quite Low
Diabetes Complications 1 31.56 Quite Low
INFLAMMATION 28 30.80 Quite Low
Cancer 34 29.28 Quite Low
Atherosclerosis 9 26.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Rat and guinea pig fetal brain cell cultures and immunoblotting techniques were used to study the effect of receptor selective opioids on the level of the membrane-bound alpha i and alpha o GTP binding protein subunits.
Regulation (effect) of GTP in brain associated with opioid
1) Confidence 0.60 Published 1990 Journal J. Neurosci. Res. Section Abstract Doc Link 2174976 Disease Relevance 0 Pain Relevance 0.10
Age-dependent changes in the subcellular distribution of rat brain mu-opioid receptors and GTP binding regulatory proteins.
Regulation (changes) of GTP in brain associated with mu opioid receptor and enkephalin
2) Confidence 0.44 Published 1991 Journal J. Neurochem. Section Title Doc Link 1655974 Disease Relevance 0 Pain Relevance 0.43
On the other hand, treatment with Boc-Cys(Npys) inhibited the effect of several GTP analogs (GTP gamma S, guanylyl-imidodiphosphate, guanylyl)-(beta, gamma-methylene)-diphosphate, and GTP) on [3H]8-OH-DPAT and [3H]clonidine binding.
Regulation (effect) of GTP associated with clonidine
3) Confidence 0.44 Published 1990 Journal Mol. Pharmacol. Section Abstract Doc Link 2166901 Disease Relevance 0.08 Pain Relevance 0.43
The results thus indicate that opioid agonists, interacting selectively with the three types of opioid receptors, induce a complex repertoire of changes in the immunoreactive levels of the membrane-bound alpha GTP binding protein subunits in various CNS structures.
Regulation (changes) of GTP associated with mu agonist and opioid receptor
4) Confidence 0.44 Published 1990 Journal J. Neurosci. Res. Section Abstract Doc Link 2174976 Disease Relevance 0 Pain Relevance 0.19
To further investigate the mechanism of regulation of PEPCK and G-6-Pase mRNA by TCA, we used primary rat hepatocytes as a model.
Spec (investigate) Regulation (regulation) of PEPCK in hepatocytes
5) Confidence 0.40 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.23 Pain Relevance 0.26
We measured the effect of TCA on the regulation of PEPCK and G-6-Pase in the chronic bile fistula rat and in primary hepatocytes.
Regulation (regulation) of PEPCK in hepatocytes associated with bile and fistula
6) Confidence 0.30 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.35 Pain Relevance 0.35
In the current study, the chronic bile fistula (CBF) rat model and primary rat hepatocytes (PRH) were used to study the regulation of gluconeogenic genes phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G-6-Pase) and the gene encoding short heterodimeric partner (SHP) by taurocholate (TCA).
Regulation (regulation) of PEPCK in bile associated with bile and fistula
7) Confidence 0.30 Published 2010 Journal Journal of Lipid Research Section Abstract Doc Link PMC2903791 Disease Relevance 0.34 Pain Relevance 0.13
mg/kg) in normal rats did not (P > 0.05) modify the mRNA level of hepatic PEPCK as compared with the vehicle-treated normal rats (data not shown).
Neg (not) Regulation (modify) of PEPCK
8) Confidence 0.19 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC516459 Disease Relevance 0.56 Pain Relevance 0
As we also know that PTX does not affect the ability of TCA to enter the cell (19), these results suggest that TCA can regulate G-6-Pase and PEPCK-1 mRNA through GPCR(s), which we have shown to activate the PI3K/PDK-1/AKT signaling cascade (17–20).
Regulation (regulate) of PEPCK-1 mRNA
9) Confidence 0.18 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.07 Pain Relevance 0.09
Bile acids have been reported to regulate the rate-limiting gluconeogenic genes phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G-6-Pase) in various cell culture and animal models (4, 23–28).
Regulation (regulate) of PEPCK in Bile associated with bile
10) Confidence 0.18 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.25 Pain Relevance 0.33
Although we do not define it as a form of chemosensory adaptation, responsiveness to external ATP and GTP is also affected by the presence of externally facing ecto-ATPases which can hydrolyze these compounds and inactivate the depolarizing stimulus.
Regulation (affected) of GTP in external
11) Confidence 0.15 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096533 Disease Relevance 0 Pain Relevance 0.07
However, these inhibitors have no effect on the responses of Tetrahymena to GTP.
Neg (no) Regulation (effect) of GTP
12) Confidence 0.11 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096533 Disease Relevance 0.19 Pain Relevance 0.13
Since the AR assay is so quick and easy, it has been used to screen for drugs that affect the responses of Tetrahymena to ATP and GTP.
Regulation (affect) of GTP
13) Confidence 0.11 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096533 Disease Relevance 0.07 Pain Relevance 0.13
The PDC assay has also been used to identify drugs and mutations that affect the GTP responses of Paramecium and to show that Mg2+ and/or Na+ are necessary to show the GTP-induced CCR.
Regulation (affect) of GTP
14) Confidence 0.11 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096533 Disease Relevance 0.15 Pain Relevance 0.10
Tyrosine kinase inhibitors have been shown to affect the GTP responses but not the ATP responses in Tetrahymena [35], supporting the idea that responses to GTP involve a sensory transduction pathway that is different than the one for ATP reception.
Neg (not) Regulation (affect) of GTP
15) Confidence 0.11 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096533 Disease Relevance 0.18 Pain Relevance 0.11
Maximally effective concentrations of GTP gamma S, Gpp(NH)p, GTP, and GDP decreased specific [3H]Me-TRH binding by 80%.
Regulation (concentrations) of GTP
16) Confidence 0.07 Published 1987 Journal J. Biol. Chem. Section Abstract Doc Link 3036863 Disease Relevance 0.16 Pain Relevance 0.20
Andrographolide not only reduced expression of phosphoenolpyruvate carboxykinase (PEPCK) in liver of STZ-diabetic rats, activated ?
Regulation (phosphoenolpyruvate) of PEPCK in liver associated with diabetes mellitus
17) Confidence 0.06 Published 2010 Journal Chin Med Section Body Doc Link PMC2881933 Disease Relevance 0.84 Pain Relevance 0.12

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