INT128444

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Context Info
Confidence 0.61
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.49
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SLC6A4) endosome (SLC6A4) plasma membrane (SLC6A4)
Anatomy Link Frequency
plasma 1
T cells 1
SLC6A4 (Homo sapiens)
Pain Link Frequency Relevance Heat
monoamine 3 99.92 Very High Very High Very High
fluoxetine 3 97.04 Very High Very High Very High
antagonist 2 96.58 Very High Very High Very High
cocaine 2 90.52 High High
Neurotransmitter 11 87.60 High High
depression 10 86.80 High High
sSRI 3 84.56 Quite High
Serotonin 9 80.80 Quite High
Dopamine 12 58.32 Quite High
Eae 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 8 86.80 High High
Increased Venous Pressure Under Development 3 75.00 Quite High
Targeted Disruption 1 70.68 Quite High
Hypertension 2 68.76 Quite High
Disease 16 50.00 Quite Low
Mental Disorders 3 50.00 Quite Low
Cancer 9 5.00 Very Low Very Low Very Low
Anxiety Disorder 6 5.00 Very Low Very Low Very Low
Cognitive Disorder 5 5.00 Very Low Very Low Very Low
Post-partum Depression 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
By performing Western blotting, real-time reverse transcriptase-polymerase chain reaction and [3H]5-HT labelling, we examined MAPK phosphorylation, 5-HTT mRNA expression and 5-HT uptake in Jurkat T cells.
Spec (examined) Phosphorylation (phosphorylation) of 5-HTT in T cells
1) Confidence 0.61 Published 2008 Journal J. Psychopharmacol. (Oxford) Section Abstract Doc Link 18308792 Disease Relevance 0.14 Pain Relevance 0.41
Some evidence also suggests that agents that cause DAT and SERT phosphorylation may regulate their removal from the plasma membrane and sequestration to an intracellular compartment.122–126 Protein kinases PKC and PKG and the p38 MAPK127 probably128 mediate these effects by modifying a C-terminal pentapeptide sequence that is homologous across the DAT, SERT, and NET proteins.
Phosphorylation (phosphorylation) of SERT in plasma
2) Confidence 0.47 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2971739 Disease Relevance 0.07 Pain Relevance 0.26
Treatment with SB224289 (selective antagonist of 5-HT1B), fluoxetine (SERT inhibitor), SERT RNA-interference, and iproniazid (monoamine oxidase-A inhibitor), blocked 5-HT-induced S100A4/Mts1. 5-HT signaling mediated phosphorylation (p) of extracellular signal-regulated kinase 1/2 (pERK1/2), but pERK1/2 nuclear translocation depended on SERT, monoamine oxidase activity, and reactive oxygen species.
Phosphorylation (phosphorylation) of SERT associated with antagonist, monoamine and fluoxetine
3) Confidence 0.34 Published 2005 Journal Circ. Res. Section Abstract Doc Link 16002749 Disease Relevance 0.28 Pain Relevance 0.35

General Comments

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