INT128654

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Context Info
Confidence 0.02
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Title
Documents 1
Total Number 2
Disease Relevance 2.69
Pain Relevance 1.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (ITIH4, CCL16) extracellular space (CCL16) plasma membrane (ITIH4)
cell-cell signaling (CCL16) cytoplasm (ITIH4)
Anatomy Link Frequency
brain 2
ITIH4 (Homo sapiens)
CCL16 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 12 100.00 Very High Very High Very High
Morphine 6 100.00 Very High Very High Very High
narcan 2 99.18 Very High Very High Very High
opiate 8 95.12 Very High Very High Very High
cytokine 2 89.84 High High
Opioid 4 87.92 High High
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 20 99.66 Very High Very High Very High
Anaplastic Astrocytoma 4 99.64 Very High Very High Very High
Neurodegenerative Disease 2 95.80 Very High Very High Very High
Glioblastoma 2 95.80 Very High Very High Very High
Drug Induced Neurotoxicity 4 93.92 High High
Infection 2 89.72 High High
Opiate Addiction 2 87.92 High High
Disease Progression 2 58.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Herein we describe the effects of morphine and/or gp120 on the expression of the genes for the beta-chemokine MIP-1beta and its receptors CCR3 and CCR5 by the U373 cells which are a human brain-derived astrocytoma/glioblastoma cell line.
gp120 Regulation (effects) of Gene_expression (expression) of chemokine in brain associated with anaplastic astrocytoma, chemokine, glioblastoma and morphine
1) Confidence 0.02 Published 2005 Journal Curr. HIV Res. Section Abstract Doc Link 16022659 Disease Relevance 1.44 Pain Relevance 0.91
Morphine exacerbates HIV-1 viral protein gp120 induced modulation of chemokine gene expression in U373 astrocytoma cells.
gp120 Regulation (modulation) of Gene_expression (expression) of chemokine associated with anaplastic astrocytoma, chemokine, acquired immune deficiency syndrome or hiv infection and morphine
2) Confidence 0.01 Published 2005 Journal Curr. HIV Res. Section Title Doc Link 16022659 Disease Relevance 1.26 Pain Relevance 0.88

General Comments

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