INT128695

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Context Info
Confidence 0.44
First Reported 2005
Last Reported 2010
Negated 6
Speculated 1
Reported most in Body
Documents 14
Total Number 15
Disease Relevance 11.49
Pain Relevance 7.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mapk14) cell morphogenesis (Mapk14) response to stress (Mapk14)
cytoplasm (Mapk14) cytosol (Mapk14) nucleus (Mapk14)
Anatomy Link Frequency
microglia 4
spinal 2
glial cell 2
spinal cord 2
neuroretina 2
Mapk14 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
intrathecal 84 100.00 Very High Very High Very High
Etanercept 26 100.00 Very High Very High Very High
fibrosis 14 99.92 Very High Very High Very High
ischemia 291 99.84 Very High Very High Very High
Perioperative pain 23 99.84 Very High Very High Very High
Hyperalgesia 22 99.76 Very High Very High Very High
allodynia 53 99.36 Very High Very High Very High
Spinal cord 111 99.04 Very High Very High Very High
Inflammation 173 99.00 Very High Very High Very High
Neuropathic pain 90 95.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cardiovascular Disorder Under Development 2 99.92 Very High Very High Very High
Cv Unclassified Under Development 210 99.84 Very High Very High Very High
Post Operative Pain 24 99.84 Very High Very High Very High
Hyperalgesia 31 99.76 Very High Very High Very High
Neuropathic Pain 151 99.36 Very High Very High Very High
INFLAMMATION 191 99.00 Very High Very High Very High
Nervous System Injury 113 98.72 Very High Very High Very High
Pressure And Volume Under Development 18 97.64 Very High Very High Very High
Brain Injury 8 96.84 Very High Very High Very High
Retina Disease 87 95.56 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Phosphorylation of ERK significantly increased but there were no significant effects on cortical expression of ERK, Jun and p-38.
Neg (no) Regulation (effects) of Gene_expression (expression) of p-38
1) Confidence 0.44 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 16024175 Disease Relevance 0.68 Pain Relevance 0.12
Evaluation of articular gene expression by quantitative real-time PCR showed that spinal p38 inhibition markedly decreased synovial interleukin-1 and ?
Regulation (spinal) of Neg (inhibition) Gene_expression (inhibition) of p38 in spinal
2) Confidence 0.43 Published 2006 Journal PLoS Medicine Section Abstract Doc Link PMC1560929 Disease Relevance 1.16 Pain Relevance 0.91
is responsible for p38 activation, CFA-immunized rats administered either IT vehicle or etanercept on days 7 and 10 were sacrificed on day 11; immunostaining and Western blot analysis on these animals showed that etanercept decreased P-p38 expression, suggesting that TNF?
Regulation (responsible) of Gene_expression (expression) of p38 associated with etanercept and intrathecal
3) Confidence 0.43 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1560929 Disease Relevance 0.41 Pain Relevance 0.63
In addition, the effect of tonabersat prior to chemical stimulation on gap junction activity and expression of connexins and active p38 was investigated.
Spec (investigated) Regulation (effect) of Gene_expression (expression) of p38
4) Confidence 0.42 Published 2009 Journal Headache Section Body Doc Link 19125874 Disease Relevance 0.07 Pain Relevance 0
The p38 family has four members: ?
Regulation (The) of Gene_expression (family) of p38
5) Confidence 0.41 Published 2008 Journal J Inflamm (Lond) Section Body Doc Link PMC2612656 Disease Relevance 0.58 Pain Relevance 0.68
Previous studies have indicated an increase in cardiac fibrosis in response to p38 MAPK overexpression and shown that adenoviral p38-injection into the heart increased CTGF mRNA expression [27].
Regulation (response) of Gene_expression (overexpression) of p38 in heart associated with fibrosis and cardiovascular disorder under development
6) Confidence 0.32 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2835668 Disease Relevance 1.24 Pain Relevance 0.17
Our data also suggest that p38 activation in spinal microglia is associated with the development of mechanical allodynia but not heat hyperalgesia, because RTX blocks heat hyperalgesia but has no effect on microglial p38 activation and mechanical allodynia after SNI.
Neg (no) Regulation (effect) of Gene_expression (activation) of p38 in microglia associated with hyperalgesia, nervous system injury and allodynia
7) Confidence 0.31 Published 2009 Journal Mol Pain Section Body Doc Link PMC2759920 Disease Relevance 1.36 Pain Relevance 1.06
In the present study, the expression levels of p38 were not affected by ischemia.
Neg (not) Regulation (affected) of Gene_expression (expression) of p38 associated with ischemia
8) Confidence 0.25 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2838742 Disease Relevance 1.67 Pain Relevance 0.50
In the lumbar tract of the spinal cord, higher levels of activated PKCgamma, ERK 1,2, p38, SAP/JNK and c-Jun proteins were detected in the ipsilateral side in respect of sham.
Regulation (detected) of Gene_expression (detected) of p38 in spinal cord associated with spinal cord
9) Confidence 0.25 Published 2010 Journal Neuroscience Section Abstract Doc Link 19925851 Disease Relevance 0.59 Pain Relevance 0.67
2A-AR activation affects the p38 pathway, we stimulated cultured KCs with NE (20 nM) and blocked either the ?
Regulation (affects) of Gene_expression (pathway) of p38
10) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2677660 Disease Relevance 0.31 Pain Relevance 0.07
For additional p38 MAP kinase pathway studies, KCs were cultured in DMEM for an 1 h (p38 phosphorylation) or 24 h (TNF-?
Regulation (cultured) of Gene_expression (studies) of p38 MAP kinase
11) Confidence 0.24 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2677660 Disease Relevance 0.14 Pain Relevance 0.21
Using this approach, we demonstrated that ECB signaling plays a functional role in the resolution of postoperative pain and in regulating the expression of glial cell markers and phosphorylated p38 (a MAPK associated with inflammation [18]).


Regulation (regulating) of Gene_expression (expression) of p38 in glial cell associated with inflammation and perioperative pain
12) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2878341 Disease Relevance 0.87 Pain Relevance 0.92
There was an early increase in ERK1/2 and c-jun levels in the neuroretina, while JNK was slightly decreased. p38 expression was not affected by ischemia.
Neg (not) Regulation (affected) of Gene_expression (expression) of p38 in neuroretina associated with ischemia
13) Confidence 0.15 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2838742 Disease Relevance 1.07 Pain Relevance 0.35
The expression of phosphorylated p38 protein and mRNA was not affected by ischemia, according to immunofluorescence, western blot, or real-time PCR analysis (Figure 8 and Figure 9).
Neg (not) Regulation (affected) of Gene_expression (expression) of p38 associated with ischemia
14) Confidence 0.15 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2838742 Disease Relevance 0.50 Pain Relevance 0.29
production in microglia through the p38-MAPK system [162,163], as an inhibitor of MAPK system will suppress production of TNF-?
Regulation (through) of Gene_expression (production) of p38 in microglia
15) Confidence 0.11 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2861665 Disease Relevance 0.84 Pain Relevance 0.57

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