INT128750

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Context Info
Confidence 0.34
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 4.35
Pain Relevance 0.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA processing (Ddx41) RNA binding (Ddx41) nucleus (Ddx41)
helicase activity (Ddx41) biological_process (Ddx41)
Anatomy Link Frequency
synovial fluid 1
neuronal 1
HeLa 1
thymocytes 1
Ddx41 (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 4 99.58 Very High Very High Very High
Arthritis 91 99.04 Very High Very High Very High
rheumatoid arthritis 31 97.80 Very High Very High Very High
Central nervous system 8 79.60 Quite High
Hippocampus 6 78.64 Quite High
abatacept 2 69.56 Quite High
cva 18 59.36 Quite High
tolerance 36 50.00 Quite Low
Morphine 4 50.00 Quite Low
Inflammation 27 42.24 Quite Low
Disease Link Frequency Relevance Heat
Immunization 165 99.32 Very High Very High Very High
Arthritis 115 99.04 Very High Very High Very High
Rheumatoid Arthritis 34 97.80 Very High Very High Very High
Amnesia 9 92.28 High High
Infection 160 91.52 High High
Cognitive Disorder 39 91.12 High High
Systemic Lupus Erythematosus 87 90.72 High High
Central Nervous System Lupus Vasculitis 3 87.80 High High
Apoptosis 48 85.48 High High
Disease 40 84.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The latter was of particular interest because only Abs capable of binding to native tetrameric M2e would be expected to display protective activity.
Abs Binding (binding) of
1) Confidence 0.34 Published 2007 Journal Virol J Section Body Doc Link PMC2186315 Disease Relevance 0.21 Pain Relevance 0
Immunosorbent-bound Abs were detected with biotinylated mAb 187 (ATCC HB58, rat-anti-mouse ?
Abs Binding (bound) of
2) Confidence 0.30 Published 2007 Journal Virol J Section Body Doc Link PMC2186315 Disease Relevance 0.12 Pain Relevance 0
Each of these peptides or combinations thereof may serve as target for MAP-induced Abs.
Abs Binding (target) of
3) Confidence 0.25 Published 2007 Journal Virol J Section Body Doc Link PMC2186315 Disease Relevance 0.26 Pain Relevance 0
We were interested in learning what fraction of the total M2e-MAP-induced Ab response was specific for M2e peptide and what fraction of the M2e-peptide-specific Abs was capable of binding to native tetrameric M2e.
Abs Binding (binding) of
4) Confidence 0.25 Published 2007 Journal Virol J Section Body Doc Link PMC2186315 Disease Relevance 0.21 Pain Relevance 0
A variable fraction (on average 15%) of these M2e(pep)-specific Abs cross-reacted with presumably native tetrameric M2e expressed by M2-transfected HeLa cells, and the concentration of these M2e(pep-nat)-specific Abs in sera of parenterally immunized mice showed a good correlation with protection against virus challenge.
Abs Binding (cross) of in HeLa
5) Confidence 0.25 Published 2007 Journal Virol J Section Body Doc Link PMC2186315 Disease Relevance 0.42 Pain Relevance 0
Some Abs, which may access the joints by crossing 'leaky' synovial blood vessels [56], remain associated with autoAgs expressed locally in the joint (for example, proteins present on the surface of articular cartilage or in the synovial fluid).
Abs Binding (associated) of in synovial fluid
6) Confidence 0.17 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888192 Disease Relevance 0.94 Pain Relevance 0.28
Binding of serum IgG Abs to thymocytes was analyzed by flow cytometry using FITC-conjugated rat anti-mouse IgG1 and IgG2a/2b (BD Pharmingen).


Abs Binding (Binding) of in thymocytes
7) Confidence 0.12 Published 2010 Journal American Journal of Transplantation Section Body Doc Link PMC2856406 Disease Relevance 0 Pain Relevance 0.07
Our data not only demonstrated a link between anti-INA aAbs and NPSLE, but also took one step further to illustrate a direct neurotoxic effect of this aAb.
aAbs Binding (link) of
8) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2886066 Disease Relevance 0.41 Pain Relevance 0.08
The presence of anti-neuronal autoantibodies (aAbs) has been identified; as examples, anti-NMDA receptors and anti-Ribsomal P aAbs have been linked to certain pathophysiological features of NPSLE.


aAbs Binding (linked) of in neuronal associated with nmda receptor
9) Confidence 0.05 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2886066 Disease Relevance 0.71 Pain Relevance 0.05
Briefly, all mice immunized with INA developed high titer anti-INA Abs 8–9 weeks after immunization (data not shown).
Abs Binding (titer) of associated with immunization
10) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2886066 Disease Relevance 0.99 Pain Relevance 0.09
Finally, it should be stressed that only a small fraction of the Abs produced in response to such multiple antigenic stimulation and complex cellular interactions are capable of binding to free haptens.
Abs Binding (binding) of
11) Confidence 0.03 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2901828 Disease Relevance 0.08 Pain Relevance 0
All the mAbs belonged to IgG1 isotype and could bind to heroin better than to morphine and codeine, which were identified by competitive inhibition ELISA.
mAbs Binding (bind) of
12) Confidence 0.00 Published 2005 Journal Di Yi Jun Yi Da Xue Xue Bao Section Body Doc Link 16027080 Disease Relevance 0 Pain Relevance 0
CONCLUSION: The anti-morphine mAbs can bind with the opioids, especially heroin, and can be useful for sensitive detection of opioids.


mAbs Binding (bind) of
13) Confidence 0.00 Published 2005 Journal Di Yi Jun Yi Da Xue Xue Bao Section Body Doc Link 16027080 Disease Relevance 0 Pain Relevance 0

General Comments

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