INT128970

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Context Info
Confidence 0.68
First Reported 2005
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 9
Disease Relevance 4.25
Pain Relevance 1.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Ncf1) cytosol (Ncf1) Golgi apparatus (Ncf1)
plasma membrane (Ncf1) cytoplasm (Ncf1)
Anatomy Link Frequency
lung 2
plasma 1
aorta 1
brain 1
kidney 1
Ncf1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 11 100.00 Very High Very High Very High
Glutamate 6 99.84 Very High Very High Very High
Clonidine 6 99.16 Very High Very High Very High
agonist 1 98.94 Very High Very High Very High
cytokine 24 98.44 Very High Very High Very High
Inflammatory response 28 97.56 Very High Very High Very High
Inflammation 60 75.00 Quite High
Hippocampus 2 72.72 Quite High
antagonist 10 50.24 Quite High
fibrosis 6 47.04 Quite Low
Disease Link Frequency Relevance Heat
Cv General 4 Under Development 8 100.00 Very High Very High Very High
Hyperoxia 92 98.66 Very High Very High Very High
INFLAMMATION 92 97.56 Very High Very High Very High
Bronchopulmonary Dysplasia 60 93.00 High High
Stress 35 91.42 High High
Necrosis 11 88.40 High High
Cancer 11 88.04 High High
Urological Neuroanatomy 36 85.36 High High
Body Weight 19 84.96 Quite High
Diabetes Mellitus 47 83.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study was undertaken to investigate the effects of the alpha2 adrenergic agonist, clonidine, on the near complete cerebral ischemia (NCFI) evoked release of glutamate and aspartate from normo- and hyperglycemic rodent brain tissue using microdialysis tissue techniques.
Localization (release) of NCFI in brain associated with glutamate, cv general 4 under development, ischemia, agonist and clonidine
1) Confidence 0.68 Published 2005 Journal Exp Brain Res Section Abstract Doc Link 16044300 Disease Relevance 0.56 Pain Relevance 0.74
These findings are consistent with the concept that the translocation of p47phox to membrane is involved in the overall activation of NDA(P)H oxidase, resulting in O2- production in aorta and kidney.
Localization (translocation) of p47phox in kidney
2) Confidence 0.43 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610641 Disease Relevance 0.27 Pain Relevance 0
Others have reported that high glucose will enhance p47phox translocation into the membrane promoting activation of NAD(P)H oxidase [56].
Localization (translocation) of p47phox
3) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909910 Disease Relevance 0.37 Pain Relevance 0
In the present study, increased expression of the p67phox protein was observed both in the cytosolic and membrane fraction in HC, and G-CSF treatment significantly attenuated hyperoxia-induced NADPH oxidase activation as evidenced by reduced membrane translocation of the p67phox in the lung tissue.
Localization (translocation) of p67phox in lung associated with hyperoxia
4) Confidence 0.38 Published 2011 Journal Yonsei Medical Journal Section Body Doc Link PMC3017710 Disease Relevance 0.72 Pain Relevance 0.03
In the present study, we have shown that aldosterone treatment induced overexpression of two membrane-bound elements (p22phox and gp91phox) and one cytosolic component (p47phox) of the NAD(P)H oxidase and its activity, and led to the translocation of the cytosolic p47phox to the plasma membrane in aorta and kidney.
Localization (translocation) of p47phox in plasma
5) Confidence 0.38 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610641 Disease Relevance 0.31 Pain Relevance 0
Western blot for p67phox membrane translocation
Localization (translocation) of p67phox
6) Confidence 0.36 Published 2011 Journal Yonsei Medical Journal Section Body Doc Link PMC3017710 Disease Relevance 0 Pain Relevance 0.09
Hyperoxia-induced activation of nicotinamide adenine dinucleotide phosphate oxidase, which is responsible for superoxide anion production, as evidenced by upregulation and membrane translocation of p67phox was significantly attenuated after G-CSF treatment, as were inflammatory responses such as increased myeloperoxidase activity and mRNA expression of transforming growth factor-?.
Localization (translocation) of p67phox associated with inflammatory response and hyperoxia
7) Confidence 0.33 Published 2011 Journal Yonsei Medical Journal Section Abstract Doc Link PMC3017710 Disease Relevance 1.08 Pain Relevance 0.19
Oxidative stress to the immature lung is a major contributing factor for the development of BPD.36 NADPH oxidase is responsible for superoxide anion production (O2-), which generates other ROS such as hydrogen peroxide, hydroxyl radical and hypochlorous acid.20 As the cytoplasmic subunits p47phox, p67phox, p40phox and Rac translocate to membrane-bound cytochrome upon activation of this multicomponent enzyme complex NADPH oxidase,37 membrane translocation of the p67phox can be served as an in vivo indicator of NADPH oxidase activation as shown in our previous study.38
Localization (translocation) of p67phox in lung associated with stress and bronchopulmonary dysplasia
8) Confidence 0.33 Published 2011 Journal Yonsei Medical Journal Section Body Doc Link PMC3017710 Disease Relevance 0.68 Pain Relevance 0.05
These findings are consistent with the concept that the translocation of p47phox to membrane is involved in the overall activation of NDA(P)H oxidase, resulting in O2- production in aorta and kidney.
Localization (translocation) of p47phox in aorta
9) Confidence 0.15 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2610641 Disease Relevance 0.27 Pain Relevance 0

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