INT128996

Context Info Confidence 0.68 First Reported 2005 Last Reported 2005 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 2 Disease Relevance 1.43 Pain Relevance 2.00

extracellular space (Ccl2, Calca) aging (Ccl2, Calca) extracellular region (Ccl2, Calca) cytoplasm (Ccl2, Calca) nucleus (Calca) intracellular (Calca)

Anatomy Link Frequency neurons 2 Ccl2 (Rattus norvegicus) Calca (Rattus norvegicus)

Pain Link Frequency Relevance Heat Calcitonin gene-related peptide 20 100.00 dorsal root ganglion 10 98.40 Hyperalgesia 2 97.12 Kinase C 6 95.28 chemokine 8 93.24 conotoxin 2 87.20 Inflammation 2 85.84 Calcium channel 2 85.12 Pain 2 78.00 nociceptor 2 25.00

Disease Link Frequency Relevance Heat Ganglion Cysts 10 98.40 Bordatella Infection 2 98.32 Hyperalgesia 2 97.12 INFLAMMATION 2 85.84 Nociception 6 81.92

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These data suggest that CCL2 and CXCL1 can stimulate CGRP release and intracellular calcium elevation in DRG neurons.

CCL2 Positive_regulation (stimulate) of Localization (release) of CGRP in neurons associated with dorsal root ganglion and calcitonin gene-related peptide

1) Confidence 0.68 Published 2005 Journal J. Neurosci. Res. Section Abstract Doc Link 16047385 Disease Relevance 0.76 Pain Relevance 1.13

The results showed that CCL2 and CXCL1 ( approximately 5-100 ng/ml) evoked CGRP release and intracellular calcium elevation in a pertussis toxin (PTX)-sensitive manner.

CCL2 Positive_regulation (evoked) of Localization (release) of CGRP associated with bordatella infection and calcitonin gene-related peptide

2) Confidence 0.49 Published 2005 Journal J. Neurosci. Res. Section Abstract Doc Link 16047385 Disease Relevance 0.67 Pain Relevance 0.87

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