INT129175

Context Info Confidence 0.28 First Reported 2005 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 3.05 Pain Relevance 0.25

lipid binding (PRAM1)

PRAM1 (Homo sapiens)

Pain Link Frequency Relevance Heat TRP channel 4 100.00 Inflammation 1 89.44 Inflammatory marker 1 81.76 Pain 2 25.00 nociceptor 1 25.00 cva 1 5.00 headache 1 5.00

Disease Link Frequency Relevance Heat Dengue Hemorrhagic Fever 67 99.84 Channelopathies 1 99.34 Dengue 63 99.24 Disease 21 99.04 INFLAMMATION 2 89.44 Targeted Disruption 2 65.12 Thrombocytopenia 1 55.84 Infection 32 16.00 Shock 12 5.00 Communicable Diseases 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

PRAM1 is down-regulated in DSS patients relative to both DHF and DF patients, as is CD14.

Negative_regulation (regulated) of PRAM1 associated with dengue and dengue hemorrhagic fever

1) Confidence 0.28 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2886038 Disease Relevance 2.10 Pain Relevance 0.04

At this point, four channelopathies have been identified in which a defect in a TRP channel-encoding gene is the direct cause of disease.

Negative_regulation (defect) of channel-encoding gene associated with trp channel, disease and channelopathies

2) Confidence 0.02 Published 2005 Journal Sci. STKE Section Abstract Doc Link 16077087 Disease Relevance 0.95 Pain Relevance 0.21

General Comments

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