INT129186

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Context Info
Confidence 0.50
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 3.01
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ATF3) nucleolus (ATF3) nucleus (ATF3)
Anatomy Link Frequency
colon 2
nerve 2
ATF3 (Homo sapiens)
Pain Link Frequency Relevance Heat
dorsal root ganglion 9 98.48 Very High Very High Very High
cINOD 14 98.32 Very High Very High Very High
Morphine 4 97.56 Very High Very High Very High
Endep 1 97.16 Very High Very High Very High
Gabapentin 2 96.44 Very High Very High Very High
Hyperalgesia 10 91.12 High High
allodynia 8 88.92 High High
Inflammation 32 82.92 Quite High
c fibre 3 79.84 Quite High
Osteoarthritis 45 73.28 Quite High
Disease Link Frequency Relevance Heat
Nervous System Injury 13 99.88 Very High Very High Very High
Cancer 160 99.36 Very High Very High Very High
Colon Cancer 103 98.96 Very High Very High Very High
Ganglion Cysts 9 98.48 Very High Very High Very High
INFLAMMATION 45 93.96 High High
Hyperalgesia 11 91.12 High High
Neuropathic Pain 20 88.92 High High
Apoptosis 14 86.96 High High
Hyperplasia 3 85.36 High High
Stress 11 83.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transcriptional regulation of activating transcription factor 3 involves the early growth response-1 gene.
Positive_regulation (involves) of Regulation (regulation) of activating transcription factor 3
1) Confidence 0.50 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 16079301 Disease Relevance 0.27 Pain Relevance 0.09
Importantly, down-regulation of ATF3 markedly increased the migration ability of colon cancer cells in vitro (Figure 3C).
Positive_regulation (increased) of Regulation (regulation) of ATF3 in colon associated with colon cancer
2) Confidence 0.50 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 1.03 Pain Relevance 0
To further validate these results, we investigated whether blocking Hsp90 also leads to ATF3 up-regulation in other human cancer cell types.
Spec (whether) Positive_regulation (leads) of Spec (whether) Regulation (regulation) of ATF3 associated with cancer
3) Confidence 0.46 Published 2010 Journal BMC Cancer Section Body Doc Link PMC3003660 Disease Relevance 0.63 Pain Relevance 0
Further characterization shows that, in the early stages, there is sensitivity to NSAIDs [173,174] whereas later stages appear to demonstrate evidence of nerve damage with elevated activating transcription factor-3 (ATF-3) immunoreactivity in innervating cell bodies of lumber-DRG and sensitivity to morphine, amitriptyline and gabapentin [173,176].
Positive_regulation (elevated) of Regulation (immunoreactivity) of activating transcription factor-3 in nerve associated with dorsal root ganglion, nervous system injury, cinod, gabapentin, endep and morphine
4) Confidence 0.11 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206352 Disease Relevance 1.08 Pain Relevance 0.93

General Comments

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