INT129312

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Context Info
Confidence 0.76
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 24
Total Number 24
Disease Relevance 18.25
Pain Relevance 3.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (SGCB) cytoskeleton organization (SGCB) cytoplasm (SGCB)
Anatomy Link Frequency
neurons 5
sensory neurons 2
salivary gland 2
ADF 1
olfactory 1
SGCB (Homo sapiens)
Pain Link Frequency Relevance Heat
Migraine 44 100.00 Very High Very High Very High
nociceptor 8 97.12 Very High Very High Very High
Hippocampus 8 88.32 High High
Serotonin 267 88.08 High High
Pain 2 88.08 High High
Angina 6 87.80 High High
headache 2 87.68 High High
Neuropeptide 51 86.76 High High
Neurotransmitter 27 83.84 Quite High
projection neuron 10 62.96 Quite High
Disease Link Frequency Relevance Heat
Carcinoma 730 100.00 Very High Very High Very High
Migraine With Aura 44 100.00 Very High Very High Very High
Acute Coronary Syndrome 32 100.00 Very High Very High Very High
Hyperoxia 888 99.44 Very High Very High Very High
Anxiety Disorder 19 99.12 Very High Very High Very High
Nociception 72 99.00 Very High Very High Very High
Cancer 640 98.24 Very High Very High Very High
Stomach Cancer 8 96.28 Very High Very High Very High
Colon Cancer 24 95.48 Very High Very High Very High
Myocardial Infarction 62 95.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The deleted region contains the beta-sarcoglycan gene (SGCB), the predicted gene SPATA18 (spermatogenesis associated 18 homolog) and several expressed sequence tags.
Gene_expression (expressed) of beta-sarcoglycan gene
1) Confidence 0.76 Published 2005 Journal Hum. Mutat. Section Abstract Doc Link 16088906 Disease Relevance 0.23 Pain Relevance 0.09
The deleted region contains the beta-sarcoglycan gene (SGCB), the predicted gene SPATA18 (spermatogenesis associated 18 homolog) and several expressed sequence tags.
Gene_expression (expressed) of SGCB
2) Confidence 0.75 Published 2005 Journal Hum. Mutat. Section Abstract Doc Link 16088906 Disease Relevance 0.23 Pain Relevance 0.09
Furthermore, statistical analysis of the relationship between SPHK1 staining and the clinicopathological characteristics of the patients revealed a significant correlation between SPHK1 expression and the clinical stage, TNM classification, and pathological differentiation of SGC, further supporting the notion that SPHK1 might play a role in the progression of SGC.
Gene_expression (progression) of SGC associated with carcinoma
3) Confidence 0.35 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2949806 Disease Relevance 0.80 Pain Relevance 0
Taken together, these observations suggested that SPHK1 protein is overexpressed in archived SGC samples.


Gene_expression (overexpressed) of SGC associated with carcinoma
4) Confidence 0.35 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2949806 Disease Relevance 0.91 Pain Relevance 0
In the current study, we report, for the first time, the characterization of SPHK1 expression in SGC of various clinicopathological grades.
Gene_expression (expression) of SGC associated with carcinoma
5) Confidence 0.35 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2949806 Disease Relevance 1.58 Pain Relevance 0
Patient survival analysis were conducted and revealed that SPHK1 protein expression in SGC was significantly associated with the survival time of patients (P < 0.001), with a correlation coefficient of -0.363, clearly indicating that the expression of SPHK1 was inversely correlated with survival time (Table 5).
Gene_expression (expression) of SGC associated with carcinoma
6) Confidence 0.35 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2949806 Disease Relevance 0.48 Pain Relevance 0
Taken together, these results indicate that the overexpression of SPHK1 is correlated with the clinical features of SGC.


Gene_expression (overexpression) of SGC associated with carcinoma
7) Confidence 0.35 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2949806 Disease Relevance 0.55 Pain Relevance 0
SPHK1 expression is associated with the prognosis of patients with SGC
Gene_expression (expression) of SGC associated with carcinoma
8) Confidence 0.31 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2949806 Disease Relevance 0.55 Pain Relevance 0
The current study was to characterize the expression of SPHK1 in salivary gland carcinomas (SGC) and to investigate the association between SPHK1 expression and progression of SGC.


Gene_expression (expression) of SGC in salivary gland associated with carcinoma
9) Confidence 0.31 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2949806 Disease Relevance 0.78 Pain Relevance 0
The current study was to characterize the expression of SPHK1 in salivary gland carcinomas (SGC) and to investigate the association between SPHK1 expression and progression of SGC.


Gene_expression (expression) of SGC in salivary gland associated with carcinoma
10) Confidence 0.31 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2949806 Disease Relevance 0.70 Pain Relevance 0
In its view, Lynch had not conclusively demonstrated that CFS families were the product of heredity: they could be chance clusters of cancer, or due to common environmental exposures, or the result of ascertainment bias.
Gene_expression (product) of families associated with cancer
11) Confidence 0.04 Published 2006 Journal Medical History Section Body Doc Link PMC1483189 Disease Relevance 0.94 Pain Relevance 0
It was all too easy, Lynch argued, for control measures to be undermined by the tides of fear, denial, evasion, guilt and apathy that he detected in patients and their families during his field investigations.60 Only by a detailed personal knowledge of patients and their families would it be possible to channel individuals to appropriate specialist care; to ensure that they got such care in a timely manner; and that they continued with care during what could be a long, painful and uncertain course of treatment.
Gene_expression (detected) of families associated with pain and anxiety disorder
12) Confidence 0.04 Published 2006 Journal Medical History Section Body Doc Link PMC1483189 Disease Relevance 0.54 Pain Relevance 0.09
We show that enzymes involved in NO signaling, including NOS and soluble guanylyl cyclase (sGC), are expressed in subsets of neurons within the M. sexta olfactory system and, moreover, that NO is produced in olfactory glomeruli in response to odor stimulation.
Gene_expression (expressed) of sGC in olfactory
13) Confidence 0.03 Published 2006 Journal Journal of Insect Science Section Body Doc Link PMC2990333 Disease Relevance 0 Pain Relevance 0.09
These neurons might sense oxygen directly through an unknown mechanism, or they might act indirectly to stimulate the activity of the sGC-expressing neurons.
Gene_expression (expressing) of sGC in neurons
14) Confidence 0.02 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1540710 Disease Relevance 0.35 Pain Relevance 0.10
The recovery of food regulation also supports the model from aggregation studies that the main site of npr-1 action is the sGC-expressing URX, AQR, and PQR neurons [18], which are not required for food regulation (Figure 4C and 4K).
Gene_expression (expressing) of sGC in neurons
15) Confidence 0.02 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1540710 Disease Relevance 0.70 Pain Relevance 0
Hyperoxia avoidance is stimulated by sGC-expressing oxygen-sensing neurons, nociceptive neurons, and ADF sensory neurons.
Gene_expression (expressing) of sGC in sensory neurons associated with nociception and hyperoxia
16) Confidence 0.02 Published 2006 Journal PLoS Biology Section Abstract Doc Link PMC1540710 Disease Relevance 0.50 Pain Relevance 0.22
Either of two sets of sGC-expressing neurons can cooperate with either of two sets of TRPV-expressing neurons to generate hyperoxia avoidance in oxygen gradients (Figure 1J and 2J).


Gene_expression (expressing) of sGC in neurons associated with hyperoxia
17) Confidence 0.02 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1540710 Disease Relevance 0.92 Pain Relevance 0.07
Four additional sGC homologs, gcy-32, gcy-34, gcy-36, and gcy-37, are coexpressed with gcy-35 and tax-4 in the URX, AQR, and PQR sensory neurons.
Gene_expression (coexpressed) of sGC in sensory neurons
18) Confidence 0.02 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1540710 Disease Relevance 0.78 Pain Relevance 0
These results provide further evidence that TRPV channel–expressing neurons cooperate with sGC-expressing neurons in the oxygen response.
Gene_expression (expressing) of sGC in neurons
19) Confidence 0.02 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1540710 Disease Relevance 0.91 Pain Relevance 0.10
At least four sets of sensory neurons promote avoidance of high oxygen: (1) some or all of URX, AQR, and PQR, which express multiple sGCs; (2) some or all of SDQ, ALN, and PLN, which express the sGC homolog gcy-35; and (3–4) the osm-9 (TRPV)–expressing neurons ADF and ASH (Figure 8A).
Gene_expression (express) of sGC in ADF
20) Confidence 0.02 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1540710 Disease Relevance 0.33 Pain Relevance 0.11

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