INT129883

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Context Info
Confidence 0.77
First Reported 2005
Last Reported 2011
Negated 0
Speculated 2
Reported most in Body
Documents 56
Total Number 60
Disease Relevance 45.42
Pain Relevance 12.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Dkk1) extracellular region (Dkk1) plasma membrane (Dkk1)
Anatomy Link Frequency
synovial fluid 8
knee 8
plasma 7
PC-3 3
osteoblast 3
Dkk1 (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 170 100.00 Very High Very High Very High
Inflammation 98 99.84 Very High Very High Very High
rheumatoid arthritis 62 99.84 Very High Very High Very High
Osteoarthritis 2176 99.64 Very High Very High Very High
spinal inflammation 35 98.96 Very High Very High Very High
imagery 28 96.88 Very High Very High Very High
Pain 93 87.20 High High
cytokine 79 83.24 Quite High
Kinase C 68 82.56 Quite High
Arthritis 62 77.80 Quite High
Disease Link Frequency Relevance Heat
Osteoporosis 405 99.98 Very High Very High Very High
Reprotox - General 1 148 99.86 Very High Very High Very High
INFLAMMATION 115 99.84 Very High Very High Very High
Rheumatoid Arthritis 62 99.84 Very High Very High Very High
Disease 868 99.80 Very High Very High Very High
Osteoarthritis 2176 99.64 Very High Very High Very High
Multiple Myeloma 115 99.28 Very High Very High Very High
Hematologic Neoplasms 12 99.24 Very High Very High Very High
Metastasis 200 99.16 Very High Very High Very High
Colitis 6 99.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition to expressing Wnts, PC-3 prostate cancer cells expressed the Wnt inhibitor DKK-1.
Gene_expression (expressed) of DKK-1 in PC-3 associated with reprotox - general 1
1) Confidence 0.77 Published 2005 Journal Cancer Res. Section Abstract Doc Link 16140917 Disease Relevance 1.64 Pain Relevance 0.07
To determine if Wnts contribute to C4-2B's ability to induce mixed osteoblastic/osteolytic lesions, C4-2B cells were stably transfected with either empty vector or DKK-1 expression vector to block Wnt activity.
Gene_expression (expression) of DKK-1 associated with osteoporosis
2) Confidence 0.77 Published 2005 Journal Cancer Res. Section Abstract Doc Link 16140917 Disease Relevance 1.26 Pain Relevance 0
Our results suggest that there is reduced systemic production of Dkk-1 in knee OA.
Gene_expression (production) of Dkk-1 in knee associated with osteoarthritis
3) Confidence 0.76 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2989312 Disease Relevance 1.22 Pain Relevance 0.52
Previous studies have shown that Dkk-1 was expressed in synovial cells, articular cartilage chondrocytes and subchondral bone osteoblasts in OA knees [10,27,28].
Gene_expression (expressed) of Dkk-1 in knees associated with osteoarthritis
4) Confidence 0.76 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2989312 Disease Relevance 1.22 Pain Relevance 0.57
This study has been the first to illustrate that Dkk-1 was detected in both plasma and synovial fluid derived from patients with primary knee OA, and that Dkk-1 were inversely related to radiographic grading of knee OA.
Gene_expression (detected) of Dkk-1 in knee associated with osteoarthritis
5) Confidence 0.76 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2989312 Disease Relevance 1.09 Pain Relevance 0.50
Additional studies will be required to determine whether the concentrations of Dkk-1 in synovial fluid and plasma are related to the expression of Dkk-1 in joint tissues.
Gene_expression (expression) of Dkk-1 in plasma
6) Confidence 0.76 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2989312 Disease Relevance 0.99 Pain Relevance 0.30
This observation suggests a significant reduction in the systemic and local expression of Dkk-1 in patient with advanced knee OA.
Gene_expression (expression) of Dkk-1 in knee associated with osteoarthritis
7) Confidence 0.76 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2989312 Disease Relevance 1.17 Pain Relevance 0.54
Thus, Lrp4 is also an osteoblast-expressed Dkk1- and sclerostin-receptor with a physiological role in the regulation of bone growth and turnover.
Gene_expression (expressed) of Dkk1 in osteoblast associated with osteoporosis
8) Confidence 0.73 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951123 Disease Relevance 0.53 Pain Relevance 0.09
Decreasing DKK-1 enabled PC-3 cells to induce osteoblastic activity, including alkaline phosphatase production and mineralization, in murine bone marrow stromal cells indicating that DKK-1 blocked Wnt-mediated osteoblastic activity in PC-3 cells.
Gene_expression (Decreasing) of DKK-1 in bone marrow associated with osteoporosis
9) Confidence 0.67 Published 2005 Journal Cancer Res. Section Abstract Doc Link 16140917 Disease Relevance 1.63 Pain Relevance 0.06
These results showed that plasma Dkk-1 levels in KL grade 3 and 4 were significantly lower than those of KL grade 2 (p < 0.001).
Gene_expression (levels) of Dkk-1 in plasma
10) Confidence 0.66 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2989312 Disease Relevance 0.23 Pain Relevance 0.12
Intriguingly, plasma Dkk-1 levels were negatively correlated with the radiographic grading of knee OA (r = -0.78, p < 0.001) (Figure 2).
Gene_expression (levels) of Dkk-1 in knee associated with osteoarthritis
11) Confidence 0.66 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2989312 Disease Relevance 0.41 Pain Relevance 0.16
The data showed that synovial fluid Dkk-1 levels in KL grade 2 and 3 were significantly elevated compared with those of KL grade 4 (p = 0.04).
Gene_expression (levels) of Dkk-1 in synovial fluid
12) Confidence 0.66 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2989312 Disease Relevance 0.32 Pain Relevance 0.13
Dickkopf-1 (Dkk-1) is a secreted protein that has been defined as a direct inhibitor of Wnt/?
Gene_expression (/) of Dkk-1
13) Confidence 0.66 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2989312 Disease Relevance 0.97 Pain Relevance 0.17
In this study, Dkk-1 levels were decreased in direct relation to the severity of knee OA.
Gene_expression (levels) of Dkk-1 in knee associated with osteoarthritis
14) Confidence 0.66 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2989312 Disease Relevance 0.99 Pain Relevance 0.36
The mechanisms of Dkk-1 reduction in the circulation and synovial fluid of OA patients remain to be investigated further.
Gene_expression (reduction) of Dkk-1 in synovial fluid associated with osteoarthritis
15) Confidence 0.66 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2989312 Disease Relevance 1.11 Pain Relevance 0.51
Previous reports have demonstrated that increased Dkk-1 levels were correlated with the pathogenesis of joint disorders [10,26,27].
Gene_expression (levels) of Dkk-1 in joint associated with arthropathy
16) Confidence 0.66 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2989312 Disease Relevance 0.98 Pain Relevance 0.35
To our knowledge, data on the relationship between Dkk-1 levels in plasma and synovial fluid and severity of knee OA have as yet not been reported in the literature.
Gene_expression (levels) of Dkk-1 in synovial fluid associated with osteoarthritis
17) Confidence 0.66 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2989312 Disease Relevance 1.08 Pain Relevance 0.49
Dickkopf1 (DKK1) is the prototype of a 4 member gene family and was first identified in 1998 [77].
Gene_expression (identified) of DKK1
18) Confidence 0.63 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951123 Disease Relevance 0.25 Pain Relevance 0
Dickkopf1 (DKK1) is the prototype of a 4 member gene family and was first identified in 1998 [77].
Gene_expression (prototype) of Dickkopf1
19) Confidence 0.63 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951123 Disease Relevance 0.25 Pain Relevance 0
Dickkopf1 (DKK1) is the prototype of a 4 member gene family and was first identified in 1998 [77].
Gene_expression (prototype) of DKK1
20) Confidence 0.63 Published 2010 Journal Journal of Osteoporosis Section Body Doc Link PMC2951123 Disease Relevance 0.25 Pain Relevance 0

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