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Context Info
Confidence 0.96
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.43
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Col1a1) extracellular region (Col1a1) proteinaceous extracellular matrix (Col1a1)
cytoplasm (Col1a1)
Anatomy Link Frequency
fibroblasts 2
extracellular matrix 1
nociceptor 1
urine 1
Col1a1 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 165 99.48 Very High Very High Very High
nociceptor 1 98.28 Very High Very High Very High
Inflammatory response 15 97.44 Very High Very High Very High
fibrosis 50 82.64 Quite High
Inflammation 70 67.96 Quite High
cytokine 9 52.40 Quite High
Bioavailability 1 38.36 Quite Low
withdrawal 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 122 99.04 Very High Very High Very High
Cramps 1 98.24 Very High Very High Very High
Urological Neuroanatomy 1 97.92 Very High Very High Very High
INFLAMMATION 70 97.24 Very High Very High Very High
Adhesions 10 93.44 High High
Apoptosis 3 93.28 High High
Fibrosis 65 92.88 High High
Phenylketonuria 8 92.60 High High
Injury 60 91.60 High High
Congenital Anomalies 1 77.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Four are involved in defense and inflammatory responses of neutrophils (NE, MPO, NGP, and CRAMP), three other overexpressed genes are related to extracellular matrix organization and degradation (COL1A1, COL1A2, and MMP13); the remainder were a nociceptor in sensory neurons (MrgA1), a structural gene of P lysozyme (Lzp-s), an immunoglobulin alpha heavy chain constant region gene (Igh-2), an osteocalcin-related protein precursor (Bglap-rs1), and a membrane-spanning 4 domain, subfamily A, member 3 (Ms4a3).
Protein_catabolism (degradation) of COL1A1 in nociceptor associated with cramps, inflammatory response, nociceptor and urological neuroanatomy
1) Confidence 0.96 Published 2005 Journal Mol. Genet. Metab. Section Abstract Doc Link 16150627 Disease Relevance 1.14 Pain Relevance 0.15
This phenotype is mostly due to impairment of osteoclast function, since the number of osteoclasts counted on bone surfaces was similar for all four backgrounds (Figure 4B), while collagen type I degradation products present in the urine of 12-week-old DKO female mice had decreased by 17% compared with WT females (Figure 4C).
Protein_catabolism (degradation) of collagen type I in urine
2) Confidence 0.21 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1899087 Disease Relevance 0 Pain Relevance 0
We demonstrated that in an in vitro setting that fibroblast-derived, but not tumor cell derived, MT1-MMP was responsible for type I collagen degradation [27].
Protein_catabolism (degradation) of I collagen in fibroblast associated with cancer and metalloproteinase
3) Confidence 0.15 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1450297 Disease Relevance 0.95 Pain Relevance 0.51
MMPs such as MMP-8, MMP-9, and MMP-13 possess the ability to degrade the extracellular matrix by breakdown of fibrillar collagen type I [9], [19], [37].
Protein_catabolism (breakdown) of collagen type I in extracellular matrix associated with metalloproteinase
4) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892485 Disease Relevance 0.89 Pain Relevance 0.20
, which is known to induce the expression of matrix molecules such as fibronectin and collagen type I [28,29] and facilitate migration of corneal fibroblasts [29,30].
Protein_catabolism (as) of collagen type I in fibroblasts
5) Confidence 0.05 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2576479 Disease Relevance 0.46 Pain Relevance 0.09

General Comments

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