INT130080

Context Info Confidence 0.53 First Reported 2005 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 6 Total Number 10 Disease Relevance 2.08 Pain Relevance 2.92

nucleus (Rxra) enzyme binding (Rxra) DNA binding (Rxra) transcription factor binding (Rxra)

Anatomy Link Frequency hepatocyte 1 Rxra (Mus musculus)

Pain Link Frequency Relevance Heat Paracetamol 26 98.48 Bile 16 96.84 cytokine 13 95.76 Inflammation 65 95.36 agonist 44 88.28 anesthesia 8 83.84 Central nervous system 17 74.80 Arthritis 2 57.28 cerebral cortex 2 51.84 Inflammatory response 12 32.08

Disease Link Frequency Relevance Heat INFLAMMATION 93 95.36 Rheumatoid Arthritis 56 94.24 Hepatotoxicity 4 85.76 Targeted Disruption 40 80.88 Injury 20 74.48 Increased Venous Pressure Under Development 1 58.12 Arthritis 2 57.28 Asthma 1 56.84 Disease 5 54.68 Infection 1 43.44

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

animal model lacks RXR?

Negative_regulation (lacks) of RXR

1) Confidence 0.53 Published 2006 Journal PPAR Research Section Body Doc Link PMC1664714 Disease Relevance 0.33 Pain Relevance 0.42

Furthermore, hepatocyte RXRalpha deficiency altered the gene expression profile of the glutathione S-transferase (Gst) family.

Negative_regulation (deficiency) of RXRalpha in hepatocyte

2) Confidence 0.40 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 16157696 Disease Relevance 0.23 Pain Relevance 1.03

In conclusion, the data presented in this study define an RXRalpha-Gst regulatory network that controls APAP-GSH conjugation.

Negative_regulation (define) of RXRalpha associated with paracetamol

3) Confidence 0.39 Published 2005 Journal Mol. Pharmacol. Section Abstract Doc Link 16157696 Disease Relevance 0.13 Pain Relevance 0.89

These mutations include RXR A416D or R421L, which specifically disrupt the formation of the RXR/TR heterodimer, and RXR A416K, which disrupts RXR/RAR and RXR/TR [58].

Negative_regulation (disrupts) of RXR

4) Confidence 0.22 Published 2009 Journal PPAR Research Section Body Doc Link PMC2801013 Disease Relevance 0 Pain Relevance 0

Competition for RXR among the partners of RXR is also intense due to the expression of multiple NRs in the same cell and the limited availability of RXR.

Negative_regulation (availability) of RXR

5) Confidence 0.22 Published 2009 Journal PPAR Research Section Body Doc Link PMC2801013 Disease Relevance 0.13 Pain Relevance 0

For instance, the Pfahl's group has reported that simultaneous mutations of L418R, L419S, and L422Q can completely abolish RXR homo- and heterodimerization [56].

Negative_regulation (abolish) of RXR

6) Confidence 0.22 Published 2009 Journal PPAR Research Section Body Doc Link PMC2801013 Disease Relevance 0 Pain Relevance 0

can also reside downstream of RXR?

Negative_regulation (downstream) of RXR

7) Confidence 0.22 Published 2009 Journal PPAR Research Section Body Doc Link PMC2801013 Disease Relevance 0 Pain Relevance 0

In the experiments, interference of RXR

Negative_regulation (interference) of RXR

8) Confidence 0.11 Published 2007 Journal PPAR Research Section Body Doc Link PMC1950239 Disease Relevance 1.26 Pain Relevance 0.49

These mutations include RXR A416D or R421L, which specifically disrupt the formation of the RXR/TR heterodimer, and RXR A416K, which disrupts RXR/RAR and RXR/TR [58].

Negative_regulation (disrupts) of RXR

9) Confidence 0.10 Published 2009 Journal PPAR Research Section Body Doc Link PMC2801013 Disease Relevance 0 Pain Relevance 0

By comparing hepatic gene expression on microarrays from germfree (GF) and conventionally-raised mice (SPF), we identified a cluster of 112 differentially expressed target genes predominantly connected to xenobiotic metabolism and pathways inhibiting RXR function.

Negative_regulation (inhibiting) of RXR

10) Confidence 0.06 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2734986 Disease Relevance 0 Pain Relevance 0.08

General Comments

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