INT130098

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Context Info
Confidence 0.42
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 5.45
Pain Relevance 1.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NOTCH1) nucleoplasm (NOTCH1) extracellular region (NOTCH1)
Golgi apparatus (NOTCH1) plasma membrane (NOTCH1) nucleus (NOTCH1)
Anatomy Link Frequency
cleavage 3
Notch 2
pancreatic ducts 1
neurites 1
body 1
NOTCH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Neurotransmitter 1 95.88 Very High Very High Very High
Chronic pancreatitis 8 92.20 High High
cINOD 21 90.88 High High
Neuritis 1 90.56 High High
Abeta 9 87.04 High High
imagery 3 86.80 High High
Inflammation 45 72.52 Quite High
Osteoarthritis 94 55.52 Quite High
palliative 1 46.32 Quite Low
cytokine 10 39.76 Quite Low
Disease Link Frequency Relevance Heat
Body Weight 8 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 4 100.00 Very High Very High Very High
Neuroblastoma 5 99.72 Very High Very High Very High
Influenza Virus Infection 178 99.60 Very High Very High Very High
Infection 101 99.30 Very High Very High Very High
Congenital Anomalies 1 96.00 Very High Very High Very High
Pancreatitis 8 92.20 High High
Cognitive Disorder 1 92.16 High High
Neuritis 1 90.56 High High
INFLAMMATION 50 90.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Exposure of differentiated human SH-SY5Y neuroblastoma cells to the Notch ligand Jagged1 induces varicosities loss all along the neurites, accompanied by the redistribution of presynaptic vesicles and the decrease in neurotransmitters release.
Negative_regulation (loss) of Notch in neurites associated with neuroblastoma, neurotransmitter and increased venous pressure under development
1) Confidence 0.42 Published 2009 Journal Dev Neurobiol Section Abstract Doc Link 19263417 Disease Relevance 0.38 Pain Relevance 0.18
The Notch pathway ligands, Jagged/Delta-like and a Notch target, HES-related repressor protein (HERP), were up-regulated in ectatic compared to normal pancreatic ducts, while another target of Notch, hairy/enhancer of split (HES), was down-regulated.
Negative_regulation (down-regulated) of Notch in pancreatic ducts
2) Confidence 0.39 Published 2008 Journal J. Pathol. Section Abstract Doc Link 18069660 Disease Relevance 1.16 Pain Relevance 0.63
Similar to its developmental role in the GI tract, Notch1 pathway activation led to an increase in hairy enhancer of split 1 (HES-1) protein and a concomitant silencing of human Notch1/HES-1/achaete-scute homolog 1.
Negative_regulation (silencing) of Notch1
3) Confidence 0.19 Published 2005 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16160079 Disease Relevance 0.70 Pain Relevance 0
These toxic effects are likely due to inhibition of Notch cleavage, a transmembrane receptor involved in regulating cell-fate decisions.
Negative_regulation (inhibition) of Notch in cleavage
4) Confidence 0.13 Published 2008 Journal Curr Top Med Chem Section Abstract Doc Link 18220933 Disease Relevance 0.87 Pain Relevance 0.43
This viral variant is more virulent in mice than the earlier influenza subtype A/HK/156/97 (H5N1), which points to the potential need for more prolonged therapy at higher dosages.47 In a more recent study, 100% survival was reported in ferrets protected with 10 day oseltamivir started before infection with influenza A/Vietnam/1203/04 (H5N1) (Table 1).46 When oseltamivir was given twice daily to these animals, clinical signs, systemic virus distribution and organ pathology were also prevented.


Negative_regulation (prevented) of H5N1 associated with influenza virus infection and infection
5) Confidence 0.04 Published 2010 Journal Journal of Antimicrobial Chemotherapy Section Body Doc Link PMC2835509 Disease Relevance 0.66 Pain Relevance 0
Notch inhibition was confirmed by transcriptional inhibition of its direct target gene, Hes1 (data not shown).


Negative_regulation (inhibition) of Notch in Notch
6) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656251 Disease Relevance 0.08 Pain Relevance 0
-induced L-PGDS expression in chondrocytes because DAPT, a Notch signalling inhibitor, blocked this process.
Negative_regulation (inhibitor) of Notch in Notch
7) Confidence 0.04 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656251 Disease Relevance 0.06 Pain Relevance 0.03
42 and reducing Notch cleavage in our experiment.
Negative_regulation (reducing) of Notch in cleavage
8) Confidence 0.03 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2405781 Disease Relevance 0 Pain Relevance 0
Specifically, the Notch cleavage activities of PS1-D385TG, PS1-DTG/DTG, PS1-D257TG and PS1-M146V have decreased by about 62%, 46%, 22% and 7%, respectively, compared to PS1wt activity (Figure 5).
Negative_regulation (decreased) of Notch in cleavage
9) Confidence 0.03 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2405781 Disease Relevance 0 Pain Relevance 0.05
Analysis of total viral yield in tissue homogenates, by qRT-PCR analysis of viral M-gene RNA level, corroborated the pandemic IFV A(H1N1) inhibition in bronchi by DAS181 (Figure 3).


Negative_regulation (inhibition) of H1N1
10) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2770640 Disease Relevance 0.64 Pain Relevance 0
DAS181 treatment completely protected against pandemic IFV A(H1N1)-induced lethality (Figure 4) and reduced pandemic IFV A(H1N1)-induced body weight loss, particularly at later time points in infection (>day 2) (Figure 5).
Negative_regulation (loss) of H1N1 in body associated with body weight and infection
11) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2770640 Disease Relevance 0.91 Pain Relevance 0

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