INT130198

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Context Info
Confidence 0.34
First Reported 2005
Last Reported 2009
Negated 1
Speculated 0
Reported most in Title
Documents 3
Total Number 3
Disease Relevance 2.60
Pain Relevance 1.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (PTGS1) small molecule metabolic process (PTGS1) aging (PTGS1)
Golgi apparatus (PTGS1) endoplasmic reticulum (PTGS1) lipid metabolic process (PTGS1)
PTGS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX2 3 100.00 Very High Very High Very High
cINOD 26 99.98 Very High Very High Very High
depression 1 93.92 High High
aspirin 3 81.52 Quite High
Inflammation 7 50.00 Quite Low
Potency 1 32.64 Quite Low
cOX1 2 25.00 Low Low
COX-2 inhibitor 3 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 8 100.00 Very High Very High Very High
Colon Cancer 11 99.84 Very High Very High Very High
Disease 8 99.04 Very High Very High Very High
INFLAMMATION 12 95.88 Very High Very High Very High
Depression 1 93.92 High High
Cancer 70 93.04 High High
Apoptosis 4 91.68 High High
Metastasis 3 89.12 High High
Hypertension 1 83.52 Quite High
Atherosclerosis 1 82.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cardiovascular toxicity of selective cyclooxygenase-2 inhibitors
Negative_regulation (inhibitors) of cyclooxygenase Binding (toxicity) of associated with toxicity
1) Confidence 0.34 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206709 Disease Relevance 1.00 Pain Relevance 0.36
Although most NSAIDs inhibit the activity of cyclooxygenase (COX), the rate-limiting enzyme in the production of prostanoids from arachidonic acid (AA), the precise mechanism through which NSAIDs act upon AD pathology remains to be elucidated.
Negative_regulation (inhibit) of cyclooxygenase Neg (inhibit) Binding (activity) of associated with cinod and disease
2) Confidence 0.15 Published 2005 Journal Neurochem. Int. Section Abstract Doc Link 16169124 Disease Relevance 0.75 Pain Relevance 0.47
Cyclooxygenase as a target for chemoprevention in colorectal cancer: lost cause or a concept coming of age?
Negative_regulation (chemoprevention) of Cyclooxygenase Binding (target) of associated with colon cancer and cox2
3) Confidence 0.11 Published 2009 Journal Expert Opin. Ther. Targets Section Title Doc Link 19236238 Disease Relevance 0.84 Pain Relevance 0.33

General Comments

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