INT130297

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Context Info
Confidence 0.56
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.06
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Abcc1) Golgi apparatus (Abcc1) ATPase activity (Abcc1)
plasma membrane (Abcc1) nucleus (Abcc1) transmembrane transport (Abcc1)
Anatomy Link Frequency
brain 2
Abcc1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 5 97.08 Very High Very High Very High
Buprenorphine 3 92.32 High High
methadone 3 85.40 High High
tolerance 20 73.88 Quite High
imagery 1 67.36 Quite High
cytokine 19 34.96 Quite Low
Inflammation 14 34.32 Quite Low
antagonist 1 17.04 Low Low
halothane 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 15 96.28 Very High Very High Very High
Apoptosis 35 95.84 Very High Very High Very High
Cancer 54 93.44 High High
Breast Cancer 6 77.24 Quite High
Autoimmune Disease 52 75.64 Quite High
Injury 3 75.00 Quite High
Stress 52 64.12 Quite High
Malignant Neoplastic Disease 10 40.32 Quite Low
INFLAMMATION 14 34.32 Quite Low
Toxicity 4 27.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Conversely, Mrp1-4 expression was differentially up-regulated.
Positive_regulation (up-regulated) of Gene_expression (expression) of Mrp1
1) Confidence 0.56 Published 2006 Journal Toxicol. Sci. Section Abstract Doc Link 16177239 Disease Relevance 0.28 Pain Relevance 0.47
These results suggest that differential expression of P-gp and possibly MRP1 contributes to the gestational-induced changes in brain and fetal uptake of saquinavir.
Positive_regulation (contributes) of Gene_expression (expression) of MRP1 in brain
2) Confidence 0.46 Published 2009 Journal J Pharm Sci Section Abstract Doc Link 19116954 Disease Relevance 0 Pain Relevance 0.46
Overexpression of Pgp, MDR-associated-protein 1 (MRP1/ABCC1) or ABCG2 has been positively correlated with the evolution of MDR as well as cross-resistance to structurally unrelated anti-neoplastic drugs in a clinical tumor burden [96].
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of MRP1 associated with cancer
3) Confidence 0.18 Published 2006 Journal Theor Biol Med Model Section Body Doc Link PMC1508139 Disease Relevance 0.78 Pain Relevance 0.04

General Comments

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