INT130356

Context Info Confidence 0.13 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.23 Pain Relevance 0.71

cytosol (Adcy10) extracellular space (Crp) lyase activity (Adcy10) plasma membrane (Adcy10) cytoskeleton (Adcy10) cytoplasm (Adcy10)

Anatomy Link Frequency Plasma 2 Adcy10 (Mus musculus) Crp (Mus musculus)

Pain Link Frequency Relevance Heat Paracetamol 8 100.00 cytokine 1 99.20

Disease Link Frequency Relevance Heat Stress 1 80.72 Hepatotoxicity 3 75.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Plasma levels of C-reactive protein (CRP), von Willebrand factor (vWF), IL-6, IL-10 and TNF-alpha were significantly increased by acetaminophen treatment (P < 0.05); and SAC or SPC intake significantly suppressed acetaminophen-induced elevation of CRP, vWF and the three cytokines (P < 0.05).

SAC Negative_regulation (suppressed) of Positive_regulation (elevation) of CRP in Plasma associated with paracetamol and cytokine

1) Confidence 0.13 Published 2006 Journal Food Chem. Toxicol. Section Abstract Doc Link 16181716 Disease Relevance 0.23 Pain Relevance 0.71

General Comments

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