INT130431

Context Info Confidence 0.60 First Reported 2005 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 1.42 Pain Relevance 0.13

nuclear envelope (DNASE1) extracellular region (DNASE1) nucleus (DNASE1)

Anatomy Link Frequency proximal 1 DNASE1 (Homo sapiens)

Pain Link Frequency Relevance Heat Crohn's disease 5 80.40 Inflammation 4 62.16 qutenza 3 50.00 abdominal pain 4 5.00 nud 2 5.00 headache 2 5.00 addiction 1 5.00 Pain 1 5.00 backache 1 5.00

Disease Link Frequency Relevance Heat Inflammatory Bowel Disease 7 98.08 Canker Sores 46 82.40 Disease 123 82.08 Skin Cancer 2 79.68 Apoptosis 2 78.96 Increased Venous Pressure Under Development 5 77.16 Ulcers 23 76.28 Thrombosis 1 65.84 INFLAMMATION 2 62.16 Hypersensitivity 1 50.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The expression of inhibitor of caspase activated DNase (ICAD) was reduced with the lapse of time.

Gene_expression (expression) of DNase

1) Confidence 0.60 Published 2005 Journal Zhonghua Zhong Liu Za Zhi Section Body Doc Link 16188123 Disease Relevance 0.16 Pain Relevance 0

DH15, located 15-kb proximal to D4Z4, was the only DH site overlapping an STR that was also detected in whole genome DNase-seq data from other cell types (data not shown).

Gene_expression (detected) of DNase in proximal

2) Confidence 0.12 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2794184 Disease Relevance 0 Pain Relevance 0

In Figure 1, we demonstrate that filtration, DNAse and RNAse treatment increases the efficiency of amplification of Adenovirus Type 17 DNA, whereas this combined treatment eliminates amplification of genomic ?

Gene_expression (filtration) of DNAse

3) Confidence 0.05 Published 2007 Journal Virol J Section Body Doc Link PMC1950496 Disease Relevance 0 Pain Relevance 0

In ulcerative colitis, the antigen recognized by pANCAs is located in the inner side of the nuclear periphery and is DNase sensitive, but the exact epitope remains yet unknown.

Gene_expression (sensitive) of DNase associated with inflammatory bowel disease

4) Confidence 0.03 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2779329 Disease Relevance 1.26 Pain Relevance 0.13

General Comments

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