INT130557

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Context Info
Confidence 0.54
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 17
Total Number 19
Disease Relevance 6.56
Pain Relevance 3.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Selp) cell adhesion (Selp) nucleus (Selp)
cytoplasm (Selp)
Anatomy Link Frequency
platelet 13
leukocyte 3
joint 2
T cells 2
Selp (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 237 99.84 Very High Very High Very High
cINOD 3 99.60 Very High Very High Very High
Versed 36 99.36 Very High Very High Very High
cytokine 111 98.96 Very High Very High Very High
chemokine 20 98.40 Very High Very High Very High
Inflammation 157 97.36 Very High Very High Very High
Arthritis 224 96.28 Very High Very High Very High
rheumatoid arthritis 26 91.96 High High
Catecholamine 12 91.76 High High
anesthesia 7 85.52 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 168 99.48 Very High Very High Very High
Adhesions 87 98.92 Very High Very High Very High
Sleep Disorders 6 97.12 Very High Very High Very High
Disease 19 97.08 Very High Very High Very High
Arthritis 254 96.28 Very High Very High Very High
Rheumatoid Arthritis 26 91.96 High High
Immune System Diseases 2 85.32 High High
Alzheimer's Dementia 2 84.44 Quite High
Immunization 16 83.52 Quite High
Spinal Cord Injury 122 79.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As reported by Chen and colleagues [35], HES 130/0.4 (Voluven®, which is routinely used in our ICU, induced transient reduction in platelet-mediated coagulation reflected by decreased platelet membrane glycoprotein and P-selectin expression in patients undergoing elective minor surgery.
Negative_regulation (decreased) of Gene_expression (expression) of P-selectin in platelet
1) Confidence 0.54 Published 2008 Journal Crit Care Section Body Doc Link PMC2481479 Disease Relevance 0.40 Pain Relevance 0.14
The preserved functionality in platelets despite decreased baseline P-selectin expression as found in the second week is in line with results from Michelson and colleagues [18], who showed that circulating platelets remain active for at least 24 hours following shedding of surface P-selectin.
Negative_regulation (decreased) of Gene_expression (expression) of P-selectin in platelets
2) Confidence 0.54 Published 2008 Journal Crit Care Section Body Doc Link PMC2481479 Disease Relevance 0.07 Pain Relevance 0
Thus, decreased baseline P-selectin expression observed in the second week does not appear to be induced by HES since patients required significantly less HES 130/0.4 compared with the first week.
Negative_regulation (decreased) of Gene_expression (expression) of P-selectin
3) Confidence 0.54 Published 2008 Journal Crit Care Section Body Doc Link PMC2481479 Disease Relevance 0.36 Pain Relevance 0.08
While P-selectin expression determines size and stability of platelet aggregates [19], reduced surface P-selectin expression does not imply functional impairment [18].
Negative_regulation (reduced) of Gene_expression (expression) of P-selectin in platelet
4) Confidence 0.47 Published 2008 Journal Crit Care Section Body Doc Link PMC2481479 Disease Relevance 0 Pain Relevance 0
However, more than 60% of CD62p expression (5.2% vs 2.0%, p<0.0001) was suppressed on day 7 after the procedure.
Negative_regulation (suppressed) of Gene_expression (expression) of CD62p
5) Confidence 0.43 Published 2005 Journal Circ. J. Section Body Doc Link 16195618 Disease Relevance 0.07 Pain Relevance 0
Additionally, only 26% of CD62p expression (5.2% vs 3.8%, p=0.026) in the study patients was suppressed at 24 h after the procedure.
Negative_regulation (suppressed) of Gene_expression (expression) of CD62p
6) Confidence 0.43 Published 2005 Journal Circ. J. Section Body Doc Link 16195618 Disease Relevance 0.07 Pain Relevance 0
Sedative agents (for example, midazolam) might have contributed to the decreased expression of platelet surface P-selectin as shown by Tsai and colleagues [30] and Gries and colleagues [31].
Negative_regulation (decreased) of Gene_expression (expression) of P-selectin in platelet associated with versed
7) Confidence 0.40 Published 2008 Journal Crit Care Section Body Doc Link PMC2481479 Disease Relevance 0.16 Pain Relevance 0.23
In addition, several anti-inflammatory drugs have been shown to decrease the expression of E-selectin and P-selectin, as well as that of other adhesion molecules, in joint tissue from patients undergoing remission [7].
Negative_regulation (decrease) of Gene_expression (expression) of P-selectin in joint associated with inflammation, cinod and adhesions
8) Confidence 0.40 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 1.38 Pain Relevance 0.56
As reported by Chen and colleagues [35], HES 130/0.4 (Voluven®, which is routinely used in our ICU, induced transient reduction in platelet-mediated coagulation reflected by decreased platelet membrane glycoprotein and P-selectin expression in patients undergoing elective minor surgery.
Negative_regulation (decreased) of Gene_expression (expression) of P-selectin in platelet
9) Confidence 0.39 Published 2008 Journal Crit Care Section Body Doc Link PMC2481479 Disease Relevance 0.40 Pain Relevance 0.14
Therefore, we investigated whether the loss of E-selectin or P-selectin affected the expression levels of five different cytokines and chemokines that are implicated in the development of CIA.
Spec (whether) Negative_regulation (loss) of Gene_expression (expression) of P-selectin associated with chemokine, arthritis and cytokine
10) Confidence 0.29 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257424 Disease Relevance 1.07 Pain Relevance 0.61
Furthermore, we observed that treatment with olprinone abolished the expression of P-selectin and ICAM-1.
Negative_regulation (abolished) of Gene_expression (expression) of P-selectin
11) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935363 Disease Relevance 0.73 Pain Relevance 0.34
Postsinusoidal rolling was further reduced to baseline following injection of an anti-P-selectin or anti-L-selectin MAb.
Negative_regulation (reduced) of Gene_expression (injection) of P-selectin
12) Confidence 0.24 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17656447 Disease Relevance 0.50 Pain Relevance 0.20
Flow cytometric analysis of P-selectin, glycoprotein IIb-IIIa and CD107a expression
Negative_regulation (analysis) of Gene_expression (expression) of P-selectin
13) Confidence 0.19 Published 2006 Journal Crit Care Section Body Doc Link PMC1751084 Disease Relevance 0 Pain Relevance 0
mice, while P-selectin expression is attenuated in both organs in these animals.29 Equally, T cells were shown to enhance the expression of TNF?
Negative_regulation (attenuated) of Gene_expression (expression) of P-selectin in T cells
14) Confidence 0.12 Published 2008 Journal Blood Section Body Doc Link PMC2602590 Disease Relevance 0.75 Pain Relevance 0.30
At 6 h after intravenous infusion, the trend of decreasing expression of activated CD42b, CD41/61 and CD62p was maintained in group H.
Negative_regulation (decreasing) of Gene_expression (expression) of CD62p
15) Confidence 0.12 Published 2006 Journal Acta Anaesthesiol Scand Section Body Doc Link 16987338 Disease Relevance 0 Pain Relevance 0
Consistent with the above data, P-selectin expression was significantly inhibited in PKC??
Negative_regulation (inhibited) of Gene_expression (expression) of P-selectin associated with kinase c
16) Confidence 0.11 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2906332 Disease Relevance 0 Pain Relevance 0.86
Three outcomes demonstrated significant UFP exposure–sex interactions (Figure 3): the numbers of leukocytes and platelets expressing CD62P and those of MP expressing CD40L.
Negative_regulation (numbers) of Gene_expression (expressing) of CD62P in platelets
17) Confidence 0.04 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC3002188 Disease Relevance 0.30 Pain Relevance 0
We assessed prostanoid metabolite excretion (PGE-M, TXB(2), 6-keto-PGF(1alpha), 11-dehydro-TXB(2), 2,3-dinor-TXB(2), and dinor-6-keto-PGF(1alpha)), the expression of platelet activation markers (CD62P, PAC-1, fibrinogen), platelet-leukocyte formation, the endogenous thrombin potential, platelet cAMP content and plasma thrombomodulin level.
Negative_regulation (assessed) of Gene_expression (expression) of CD62P in leukocyte
18) Confidence 0.04 Published 2007 Journal J. Thromb. Haemost. Section Body Doc Link 17916229 Disease Relevance 0 Pain Relevance 0
Three outcomes demonstrated significant UFP exposure–sex interactions (Figure 3): the numbers of leukocytes and platelets expressing CD62P and those of MP expressing CD40L.
Negative_regulation (numbers) of in leukocytes Gene_expression (expressing) of CD62P in platelets
19) Confidence 0.01 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC3002188 Disease Relevance 0.30 Pain Relevance 0

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