INT13063

Context Info Confidence 0.38 First Reported 1991 Last Reported 2010 Negated 1 Speculated 0 Reported most in Abstract Documents 16 Total Number 16 Disease Relevance 6.54 Pain Relevance 1.22

Anatomy Link Frequency pancreas 1 pigmentation 1 body 1 RHCE (Homo sapiens)

Pain Link Frequency Relevance Heat melanocortin 1 receptor 165 97.54 Chronic pancreatitis 4 96.36 Clonidine 7 89.68 Multiple sclerosis 8 50.00 headache 3 40.56 Pain 5 37.68 depression 16 5.00 imagery 12 5.00 tolerance 4 5.00 Inflammation 1 5.00

Disease Link Frequency Relevance Heat Melanoma 154 99.66 Renal Failure 4 99.44 Growth Hormone Deficiency 133 99.28 Toxicity 2 99.24 Acromegaly 128 99.00 Pancreatic Cancer 5 97.60 Pancreatitis 4 96.36 Hypophysis Disease 24 95.64 Hypercalcemia 12 92.32 Disease 21 89.04

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The coding sequence is highly polymorphic in human populations, with several of these variant forms of the receptor now known to be associated with the RHC phenotype.

RHC Binding (associated) of

1) Confidence 0.38 Published 2002 Journal Melanoma Res. Section Abstract Doc Link 12394181 Disease Relevance 0.72 Pain Relevance 0.09

RESULTS: The association between RHC variant genotype and MS was more evident for women (odds ratio 2.02 [1.15-3.54]) than for men (odds ratio 0.65 [0.27-1.57]) (difference in effect, p = 0.03).

RHC Binding (association) of

2) Confidence 0.36 Published 2008 Journal Neurology Section Body Doc Link 18711112 Disease Relevance 0.17 Pain Relevance 0

The RHC variant genotype was associated with behavioral sun avoidance.

RHC Binding (associated) of

3) Confidence 0.36 Published 2008 Journal Neurology Section Body Doc Link 18711112 Disease Relevance 0.15 Pain Relevance 0

The V60L, V92M and R163Q weakly associated RHC alleles, designated 'r', were expressed with normal or intermediate cell surface receptor levels.

RHC Binding (associated) of

4) Confidence 0.34 Published 2005 Journal Hum. Mol. Genet. Section Abstract Doc Link 15972726 Disease Relevance 0.14 Pain Relevance 0

The possibility that altered cellular localization of the R151C and R160W variant receptors could underlie their association with RHC was therefore considered.

RHC Binding (association) of

5) Confidence 0.34 Published 2005 Journal Hum. Mol. Genet. Section Abstract Doc Link 15972726 Disease Relevance 0.16 Pain Relevance 0.07

In conclusion, the effects of rhGH replacement in patients with GHD after treatment for acromegaly seem to be limited.

rhGH Binding (replacement) of associated with acromegaly and growth hormone deficiency

6) Confidence 0.22 Published 2009 Journal Pituitary Section Body Doc Link PMC2764055 Disease Relevance 1.14 Pain Relevance 0

Replacement with rhGH did not improve QoL parameters.

rhGH Binding (Replacement) of

7) Confidence 0.22 Published 2009 Journal Pituitary Section Body Doc Link PMC2764055 Disease Relevance 1.20 Pain Relevance 0

Replacement with rhGH in those patients seems to modestly increase bone mineral density after 1 year [27].

rhGH Binding (Replacement) of

8) Confidence 0.22 Published 2009 Journal Pituitary Section Body Doc Link PMC2764055 Disease Relevance 0.53 Pain Relevance 0

Nonetheless, rhGH replacement did not alter cardiac function, lipid and glucose concentrations, body composition or QoL.

rhGH Binding (replacement) of in body

9) Confidence 0.22 Published 2009 Journal Pituitary Section Abstract Doc Link PMC2764055 Disease Relevance 0.30 Pain Relevance 0

To test the efficacy and toxicity of recombinant human growth hormone (rhGH, Protropin, Genentech), we reviewed our experience of its administration of rhGH to pediatric renal transplant recipients.

rhGH Binding (administration) of associated with toxicity and renal failure

10) Confidence 0.18 Published 1993 Journal Kidney Int. Suppl. Section Abstract Doc Link 8246373 Disease Relevance 0.27 Pain Relevance 0.09

To test the efficacy and toxicity of recombinant human growth hormone (rhGH, Protropin, Genentech), we reviewed our experience of its administration of rhGH to pediatric renal transplant recipients.

rhGH Binding (administration) of associated with toxicity and renal failure

11) Confidence 0.18 Published 1993 Journal Kidney Int. Suppl. Section Abstract Doc Link 8246373 Disease Relevance 0.27 Pain Relevance 0.09

To avoid daily injections, a long-acting GH molecule has been obtained by covalent binding of polyethylene glycol (PEG) with rhGH (PEG-GH), allowing weekly s.c. injections.

rhGH Binding (binding) of

12) Confidence 0.13 Published 2009 Journal Eur. J. Endocrinol. Section Abstract Doc Link 19654233 Disease Relevance 0.07 Pain Relevance 0

LH-RH-, estrogen-, and progesterone-receptor binding was measured in the human pancreas of patients with ductal pancreatic cancer (n = 23) and chronic pancreatitis (n = 15), and of organ donors (n = 11).

LH-RH Binding (binding) of in pancreas associated with pancreatic cancer and chronic pancreatitis

13) Confidence 0.13 Published 1991 Journal Int. J. Pancreatol. Section Abstract Doc Link 1660910 Disease Relevance 0.38 Pain Relevance 0.16

In previous studies investigating the associations of MC1R variants with melanoma, whether conducted in case–control series or melanoma-prone families, the melanoma risk was mainly associated with the RHC variants, although it has also been reported to be influenced by certain NRHC variants (12,13–16), indicating that MC1R plays a role in melanoma development beyond that of pigmentation.

RHC Binding (associated) of in pigmentation associated with melanocortin 1 receptor and melanoma

14) Confidence 0.07 Published 2010 Journal JNCI Journal of the National Cancer Institute Section Body Doc Link PMC2957428 Disease Relevance 1.03 Pain Relevance 0.72

Sixteen healthy elderly women (mean age +/- SEM, 71.9 +/- 1.3 yr) were randomly assigned to receive either rhGH (GH; n = 5), low dose rhIGF-I (n = 6), or high dose rhIGF-I (n = 5).

rhGH Binding (receive) of

15) Confidence 0.05 Published 1995 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 7539817 Disease Relevance 0 Pain Relevance 0

containing these residues were not able to recognize anti-rhGH

rhGH Neg (not) Binding (recognize) of

16) Confidence 0.02 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC551587 Disease Relevance 0 Pain Relevance 0

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