INT1307

From wiki-pain
Revision as of 16:03, 23 September 2012 by Daniel (Talk | contribs)

(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to: navigation, search
Context Info
Confidence 0.70
First Reported 1977
Last Reported 2010
Negated 9
Speculated 5
Reported most in Abstract
Documents 120
Total Number 125
Disease Relevance 24.58
Pain Relevance 58.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pomc) generation of precursor metabolites and energy (Pomc) extracellular space (Pomc)
extracellular region (Pomc) molecular_function (Pomc) cell-cell signaling (Pomc)
Anatomy Link Frequency
pituitary 38
plasma 15
adrenal gland 12
hypothalamus 8
brain 8
Pomc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 132 100.00 Very High Very High Very High
narcan 94 100.00 Very High Very High Very High
Enkephalin 69 100.00 Very High Very High Very High
gABA 46 100.00 Very High Very High Very High
Endogenous opioid 44 100.00 Very High Very High Very High
analgesia 40 100.00 Very High Very High Very High
Dynorphin 38 100.00 Very High Very High Very High
opiate 37 100.00 Very High Very High Very High
qutenza 22 100.00 Very High Very High Very High
electroacupuncture 21 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 277 100.00 Very High Very High Very High
Nociception 14 99.80 Very High Very High Very High
Anxiety Disorder 20 99.70 Very High Very High Very High
Urological Neuroanatomy 13 99.68 Very High Very High Very High
Diabetes Mellitus 88 99.64 Very High Very High Very High
INFLAMMATION 132 99.04 Very High Very High Very High
Fever 10 98.84 Very High Very High Very High
Lordosis 10 98.46 Very High Very High Very High
Hypotension 13 98.00 Very High Very High Very High
Depression 59 97.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The in vitro release of beta-endorphin-related peptides from the anterior pituitary was increased; the tissue concentrations, however, remained unchanged.
Positive_regulation (increased) of Localization (release) of beta-endorphin in anterior pituitary
1) Confidence 0.70 Published 1984 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6086890 Disease Relevance 0 Pain Relevance 0.06
These findings indicate that dopaminergic neurons in the arcuate nucleus may induce the secretion of beta-endorphin in the nucleus accumbens, and that they are implicated in the cocaine reward pathway.
Spec (may) Positive_regulation (induce) of Localization (secretion) of beta-endorphin in nucleus accumbens associated with nucleus accumbens and cocaine
2) Confidence 0.69 Published 2006 Journal Neuroreport Section Abstract Doc Link 17001283 Disease Relevance 0 Pain Relevance 0.59
Nociceptive stimulus induces release of endogenous beta-endorphin in the rat brain.
Positive_regulation (induces) of Localization (release) of beta-endorphin in brain associated with nociceptor
3) Confidence 0.69 Published 1998 Journal Neuroscience Section Title Doc Link 9639262 Disease Relevance 0.35 Pain Relevance 0.66
Furthermore, in vitro studies showed that the spontaneous and K(+)-stimulated release of beta-endorphin from the hypothalamus of rats which had been exposed to a conditioned stimulus was enhanced, whereas the release of alpha-neoendorphin from that tissue was attenuated.
Positive_regulation (enhanced) of Localization (release) of beta-endorphin in hypothalamus
4) Confidence 0.69 Published 1990 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 1982694 Disease Relevance 0.43 Pain Relevance 0.60
Experiments were carried out in vivo and in vitro on white rats and it was established that analgin, aminton and analgeton stimulated the release of beta-endorphin, affecting various regulatory levels.
Positive_regulation (stimulated) of Localization (release) of beta-endorphin
5) Confidence 0.69 Published 1989 Journal Eksp Med Morfol Section Abstract Doc Link 2530083 Disease Relevance 0.35 Pain Relevance 0.47
It was concluded that during acute exercise the activation of the opioid system is mainly based on the augmented release of beta-endorphin.
Positive_regulation (augmented) of Localization (release) of beta-endorphin associated with opioid
6) Confidence 0.69 Published 1991 Journal Int J Sports Med Section Abstract Doc Link 1752719 Disease Relevance 0 Pain Relevance 0.10
However, serotonin-induced beta-endorphin release was impaired in FSL rats.
Positive_regulation (induced) of Localization (release) of beta-endorphin associated with serotonin
7) Confidence 0.69 Published 2002 Journal Neuroscience Section Abstract Doc Link 11906780 Disease Relevance 0.38 Pain Relevance 0.75
Previously we showed that serotonin (5-hydroxytryptamine) facilitates beta-endorphin release in the nucleus accumbens (NAcc).
Positive_regulation (facilitates) of Localization (release) of beta-endorphin in NAcc associated with nucleus accumbens and serotonin
8) Confidence 0.69 Published 2002 Journal Neuroscience Section Abstract Doc Link 11906780 Disease Relevance 0.26 Pain Relevance 0.53
However, the chronic antidepressant treatment did normalize the serotonin-induced release of beta-endorphin in FSL rats, as well as their behavioral manifestation of depressive behavior.
Positive_regulation (induced) of Localization (release) of beta-endorphin associated with antidepressant, depression and serotonin
9) Confidence 0.69 Published 2002 Journal Neuroscience Section Abstract Doc Link 11906780 Disease Relevance 0.41 Pain Relevance 0.77
Clonidine, fluoxetine and naloxone administration before therapy was not able to stimulate the release of beta-endorphin, but the response was completely restored after raloxifene administration.
Positive_regulation (stimulate) of Localization (release) of beta-endorphin associated with narcan, fluoxetine and clonidine
10) Confidence 0.68 Published 2001 Journal Gynecol. Endocrinol. Section Abstract Doc Link 11727358 Disease Relevance 0 Pain Relevance 0.88
Noradrenaline, injected directly into inflamed hind paws of male Wistar rats, produced dose-dependent antinociception, reversible by alpha(1)-, alpha(2)- and beta(2)-antagonists. alpha(1)-, alpha(2)- and beta(2)-adrenergic receptors were demonstrated on beta-endorphin-containing immune cells and noradrenaline induced adrenergic receptor-specific release of beta-endorphin from immune cell suspensions.
Positive_regulation (induced) of Localization (release) of beta-endorphin in immune cells associated with antinociception, antagonist and noradrenaline
11) Confidence 0.68 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15245482 Disease Relevance 0.17 Pain Relevance 1.17
Caffeine stimulates beta-endorphin release in blood but not in cerebrospinal fluid.
Positive_regulation (stimulates) of Localization (release) of beta-endorphin in blood associated with narcan
12) Confidence 0.67 Published 1982 Journal Life Sci. Section Title Doc Link 6290811 Disease Relevance 0 Pain Relevance 0.26
This suggests that the posttraining treatments that affect endogenous opioid function affect memory only of the task(s) that actually cause the release of brain beta-endorphin (in this case, probably habituation), and not of others that may occur simultaneously but are merely incidental (water-finding).
Neg (not) Positive_regulation (cause) of Localization (release) of brain beta-endorphin in brain associated with endogenous opioid
13) Confidence 0.67 Published 1986 Journal Psychoneuroendocrinology Section Abstract Doc Link 2951761 Disease Relevance 0.31 Pain Relevance 0.67
These results suggest that EAA and the increased release of beta-endorphin caused by EA are related to the activation of alpha 2-adrenergic receptor in the spinal cord.
Positive_regulation (caused) of Localization (release) of beta-endorphin in spinal cord associated with electroacupuncture, spinal cord and analgesia
14) Confidence 0.67 Published 1996 Journal Zhen Ci Yan Jiu Section Abstract Doc Link 9387357 Disease Relevance 0.18 Pain Relevance 0.92
These results suggest that EAA and the increased release of beta-endorphin caused by EA are related to the activation of alpha 2-adrenergic receptor in the spinal cord.
Positive_regulation (increased) of Localization (release) of beta-endorphin in spinal cord associated with electroacupuncture, spinal cord and analgesia
15) Confidence 0.67 Published 1996 Journal Zhen Ci Yan Jiu Section Abstract Doc Link 9387357 Disease Relevance 0.18 Pain Relevance 0.92
In conclusion, our results suggest that puerarin may activate alpha (1)-adrenoceptors on the adrenal gland to enhance the secretion of beta-endorphin to result in a decrease of plasma glucose in STZ-diabetic rats.
Positive_regulation (enhance) of Localization (secretion) of beta-endorphin in plasma associated with diabetes mellitus
16) Confidence 0.66 Published 2004 Journal Planta Med. Section Abstract Doc Link 14994187 Disease Relevance 0.74 Pain Relevance 0.18
The mu-opioid agonist DAMGO ([D-Ala(2), N-Me-Phe(4), Gly(5)-ol]enkephalin) significantly stimulated beta-endorphin and alpha-melanocyte-stimulating hormone release relative to controls early (30 min) in the incubation period.
Positive_regulation (stimulated) of Localization (release) of beta-endorphin in melanocyte associated with mu agonist and enkephalin
17) Confidence 0.60 Published 2000 Journal Neuropeptides Section Abstract Doc Link 10688972 Disease Relevance 0 Pain Relevance 0.89
Cocaine induced secretion of ACTH, beta-endorphin, and corticosterone.
Positive_regulation (induced) of Localization (secretion) of beta-endorphin associated with cocaine
18) Confidence 0.57 Published 1987 Journal Peptides Section Title Doc Link 2829143 Disease Relevance 0 Pain Relevance 0.35
The results suggest that pyrogens enhance beta-endorphin release in the hypothalamus and trigger fever which can be attenuated by buprenorphine, an opioid receptor antagonist.
Positive_regulation (enhance) of Localization (release) of beta-endorphin in hypothalamus associated with antagonist, opioid receptor, fever and buprenorphine
19) Confidence 0.54 Published 2003 Journal J. Pharmacol. Sci. Section Abstract Doc Link 14578583 Disease Relevance 0.42 Pain Relevance 0.65
Pyrogens enhance beta-endorphin release in hypothalamus and trigger fever that can be attenuated by buprenorphine.
Positive_regulation (enhance) of Localization (release) of beta-endorphin in hypothalamus associated with fever and buprenorphine
20) Confidence 0.54 Published 2003 Journal J. Pharmacol. Sci. Section Title Doc Link 14578583 Disease Relevance 0.31 Pain Relevance 0.40

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox