INT130721

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Context Info
Confidence 0.05
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 5.29
Pain Relevance 2.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL1B, IL1RN) extracellular region (IL1B, IL1RN) aging (IL1B)
intracellular (IL1RN) cytoplasm (IL1RN) cell-cell signaling (IL1B)
Anatomy Link Frequency
synovial fluid 1
IL1B (Homo sapiens)
IL1RN (Homo sapiens)
Pain Link Frequency Relevance Heat
anakinra 23 100.00 Very High Very High Very High
antagonist 15 99.98 Very High Very High Very High
Osteoarthritis 249 99.18 Very High Very High Very High
rheumatoid arthritis 177 98.70 Very High Very High Very High
Inflammation 119 98.40 Very High Very High Very High
Pain 18 94.72 High High
cytokine 124 93.52 High High
spinal inflammation 4 90.24 High High
headache 4 85.40 High High
psoriasis 44 83.00 Quite High
Disease Link Frequency Relevance Heat
Disease Progression 10 99.82 Very High Very High Very High
Osteoarthritis 252 99.18 Very High Very High Very High
Rheumatoid Arthritis 178 98.70 Very High Very High Very High
INFLAMMATION 109 98.40 Very High Very High Very High
Autoimmune Disease 33 97.52 Very High Very High Very High
Pain 16 94.72 High High
Necrosis 16 92.20 High High
Cancer 16 91.84 High High
Low Back Pain 4 90.24 High High
Fatigue 2 85.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-1 receptor antagonist (IL-1Ra) acts as a natural IL-1 inhibitor preventing the interaction of IL-1 with its cell surface receptors.
IL-1 Binding (interaction) of IL-1Ra associated with antagonist
1) Confidence 0.05 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 1.33 Pain Relevance 0.61
This IL-1Trap preferentially binds IL-1?.
IL-1 Binding (binds) of IL-1Trap
2) Confidence 0.03 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526599 Disease Relevance 0.28 Pain Relevance 0.18
Nevertheless, even if IL-1ra levels are increased in the synovial fluid in vivo, it is uncertain if these IL-1ra levels correlate with OA symptoms or disease progression, as the ratio of IL-1ra to IL-1?
IL-1 Binding (ratio) of IL-1ra in synovial fluid associated with osteoarthritis and disease progression
3) Confidence 0.01 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911907 Disease Relevance 0.73 Pain Relevance 0.40
Current therapy targeting IL-1 in RA is based on a recombinant form of the IL-1 receptor antagonist (IL-1Ra; anakinra), which binds to the IL-1 receptor without eliciting a signal and therefore competes with the binding of the two natural ligands, namely IL-1?
IL-1 Binding (binding) of IL-1Ra associated with anakinra, antagonist and rheumatoid arthritis
4) Confidence 0.01 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483458 Disease Relevance 1.23 Pain Relevance 0.62
Current therapy targeting IL-1 in RA is based on a recombinant form of the IL-1 receptor antagonist (IL-1Ra; anakinra), which binds to the IL-1 receptor without eliciting a signal and therefore competes with the binding of the two natural ligands, namely IL-1?
IL-1 Binding (binds) of IL-1Ra associated with anakinra, antagonist and rheumatoid arthritis
5) Confidence 0.01 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483458 Disease Relevance 1.15 Pain Relevance 0.58
IL-1 receptor antagonist (IL-1Ra) is a protein that binds to IL-1 receptors and competitively inhibits the binding of IL-1alpha and IL-1beta.
IL-1 Binding (binds) of antagonist associated with antagonist
6) Confidence 0.00 Published 2005 Journal J. Rheumatol. Section Abstract Doc Link 16206345 Disease Relevance 0.57 Pain Relevance 0.46

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