INT130784

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Context Info
Confidence 0.54
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 4.90
Pain Relevance 2.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Arc) plasma membrane (Arc) cytoskeleton (Arc)
cytoskeleton organization (Arc) cytoplasm (Arc)
Anatomy Link Frequency
nucleus accumbens 3
neurons 2
striatum 1
Arc (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 24 100.00 Very High Very High Very High
tolerance 3 99.60 Very High Very High Very High
opiate 3 99.18 Very High Very High Very High
Nucleus accumbens 6 97.08 Very High Very High Very High
Opioid 3 92.72 High High
antagonist 3 92.16 High High
long-term potentiation 3 92.00 High High
opioid receptor 9 91.92 High High
withdrawal 3 89.52 High High
mu opioid receptor 3 75.00 Quite High
Disease Link Frequency Relevance Heat
Aids-related Complex 276 100.00 Very High Very High Very High
Neuroblastoma 3 75.00 Quite High
Injury 6 5.00 Very Low Very Low Very Low
Feminization 6 5.00 Very Low Very Low Very Low
Overdose 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After prolonged opiate treatment, tolerance to the stimulatory effect of morphine on Arc expression developed.
Regulation (effect) of Gene_expression (expression) of Arc associated with aids-related complex, tolerance, opiate and morphine
1) Confidence 0.54 Published 2005 Journal J. Neurosci. Res. Section Abstract Doc Link 16211563 Disease Relevance 0.89 Pain Relevance 1.23
To more accurately measure changes in ARC Kiss1 expression during development, total RNA was extracted from the ARC and used to measure Kiss1 mRNA levels by qRT-PCR in male and female WT and hpg mice at ages 10, 30, 45 and 60 days.
Regulation (changes) of Gene_expression (expression) of ARC associated with aids-related complex
2) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912854 Disease Relevance 0.96 Pain Relevance 0
There were no significant changes in ARC Kiss1 mRNA levels across maturation in either WT females or males (P>0.05; ANOVA).
Neg (no) Regulation (changes) of Gene_expression (levels) of ARC associated with aids-related complex
3) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912854 Disease Relevance 0.73 Pain Relevance 0
In the present experiments, the influence of morphine on Arc expression was assessed by quantitative reverse transcription real-time PCR and Western blotting in vivo in the mouse striatum/nucleus accumbens and, in vitro, in the mouse Neuro2A MOR1A cell line, expressing mu-opioid receptor.
Regulation (influence) of Gene_expression (expression) of Arc in nucleus accumbens associated with nucleus accumbens, aids-related complex, opioid receptor and morphine
4) Confidence 0.27 Published 2005 Journal J. Neurosci. Res. Section Abstract Doc Link 16211563 Disease Relevance 0.64 Pain Relevance 0.80
These findings indicated that the clusters of enlarged kisspeptin-immunoreactive neurons in the ARC of hpg females and males represent neurons undergoing robust Kiss1 expression.


Regulation (enlarged) of Gene_expression (neurons) of ARC in neurons associated with aids-related complex
5) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912854 Disease Relevance 1.05 Pain Relevance 0
In the present experiments, the influence of morphine on Arc expression was assessed by quantitative reverse transcription real-time PCR and Western blotting in vivo in the mouse striatum/nucleus accumbens and, in vitro, in the mouse Neuro2A MOR1A cell line, expressing mu-opioid receptor.
Regulation (influence) of in striatum Gene_expression (expression) of Arc in nucleus accumbens associated with nucleus accumbens, aids-related complex, opioid receptor and morphine
6) Confidence 0.09 Published 2005 Journal J. Neurosci. Res. Section Abstract Doc Link 16211563 Disease Relevance 0.64 Pain Relevance 0.80

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