INT131184

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Context Info
Confidence 0.63
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 2.47
Pain Relevance 1.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IGF1) extracellular space (IGF1) extracellular region (IGF1)
plasma membrane (PTGER2) signal transducer activity (PTGER2)
Anatomy Link Frequency
PGE2 4
PTGER2 (Homo sapiens)
IGF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 38 99.64 Very High Very High Very High
cINOD 2 98.28 Very High Very High Very High
Inflammation 2 55.92 Quite High
COX2 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Osteoarthritis 40 99.64 Very High Very High Very High
INFLAMMATION 4 97.80 Very High Very High Very High
Sclerosis 6 62.12 Quite High
Osteophyte 2 54.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Under basal condition, OA Ob expressed similar IGF-1 mRNA to normal Ob; however, PGE2 stimulated IGF-1 mRNA expression more in OA than normal Ob.
PGE2 Positive_regulation (stimulated) of Gene_expression (expression) of IGF-1 mRNA in PGE2 associated with osteoarthritis
1) Confidence 0.63 Published 2006 Journal Bone Section Abstract Doc Link 16257278 Disease Relevance 0.93 Pain Relevance 0.60
The PGE2-dependent stimulation of IGF-1 synthesis was due in part to the cAMP/protein kinase A pathway since both the direct inhibition of this pathway with H-89 and the inhibition of EP2 or EP4 receptors, linked to cAMP production, reduced IGF-1 synthesis.
PGE2 Positive_regulation (stimulation) of Gene_expression (synthesis) of IGF-1 in PGE2
2) Confidence 0.37 Published 2006 Journal Bone Section Abstract Doc Link 16257278 Disease Relevance 1.54 Pain Relevance 0.70

General Comments

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