INT131433

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Context Info
Confidence 0.30
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 0.99
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MAPKAPK2) nucleoplasm (MAPKAPK2) small molecule metabolic process (MAPKAPK2)
nucleus (MAPKAPK2) response to stress (MAPKAPK2) cytoplasm (MAPKAPK2)
Anatomy Link Frequency
finger 1
MAPKAPK2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 72 96.24 Very High Very High Very High
Inflammation 62 92.24 High High
Inflammatory response 4 92.12 High High
cINOD 2 80.24 Quite High
rheumatoid arthritis 8 5.00 Very Low Very Low Very Low
Arthritis 6 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 8 97.16 Very High Very High Very High
INFLAMMATION 66 92.24 High High
Aging 2 88.80 High High
Sprains And Strains 2 40.00 Quite Low
Hypersensitivity Pneumonitis 2 34.88 Quite Low
Autoimmune Disease 28 5.00 Very Low Very Low Very Low
Disease 20 5.00 Very Low Very Low Very Low
Hypersensitivity 14 5.00 Very Low Very Low Very Low
Stress 12 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Phosphorylation of TTP by MK2 has been shown to induce the binding of 14-3-3 proteins to TTP, thereby withholding TTP from the mRNA degradation machinery [97,98].
Phosphorylation (Phosphorylation) of MK2
1) Confidence 0.30 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0.08 Pain Relevance 0.17
One mechanism by which MK2 may regulate mRNA stability is through the phosphorylation and inactivation of the zinc finger protein TTP.
Phosphorylation (phosphorylation) of MK2 in finger
2) Confidence 0.30 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0.09 Pain Relevance 0.16
We have shown that MK2 directly phosphorylates HSF1 and inhibits activity by decreasing its ability to bind the heat shock elements (HSE) found in the promoters of target genes encoding the HSP molecular chaperones and cytokine genes.
Phosphorylation (phosphorylates) of MK2 associated with shock and cytokine
3) Confidence 0.25 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16278218 Disease Relevance 0.41 Pain Relevance 0.19
We show that activation of HSF1 to bind HSE in hsp promoters is inhibited through the phosphorylation of a specific residue, serine 121 by MK2.
Phosphorylation (phosphorylation) of MK2
4) Confidence 0.21 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16278218 Disease Relevance 0.40 Pain Relevance 0.21

General Comments

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