INT131567

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Context Info
Confidence 0.41
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.66
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Bcl2l1) intracellular (Bcl2l1) response to stress (Bcl2l1)
cytoplasm (Bcl2l1) cytosol (Bcl2l1) cell proliferation (Bcl2l1)
Bcl2l1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 6 99.28 Very High Very High Very High
Thalamus 1 96.96 Very High Very High Very High
cerebral cortex 1 96.08 Very High Very High Very High
isoflurane 1 86.60 High High
Versed 1 86.12 High High
Disease Link Frequency Relevance Heat
Apoptosis 8 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Melatonin-induced neuroprotection was mediated, at least in part, via the inhibition of mitochondria-dependent apoptotic pathway since melatonin caused an up-regulation of the anti-apoptotic protein, bcl-X(L), reduction in anesthesia-induced cytochrome c release into the cytoplasm and a decrease in anesthesia-induced activation of caspase-3, an important step in the activation of DNAses and the formation of the apoptotic bodies.
Negative_regulation (inhibition) of Positive_regulation (caused) of bcl-X associated with anesthesia and apoptosis
1) Confidence 0.41 Published 2006 Journal Neurobiol. Dis. Section Abstract Doc Link 16289675 Disease Relevance 0.66 Pain Relevance 0.70

General Comments

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