INT131567

Context Info Confidence 0.41 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.66 Pain Relevance 0.70

mitochondrion (Bcl2l1) intracellular (Bcl2l1) response to stress (Bcl2l1) cytoplasm (Bcl2l1) cytosol (Bcl2l1) cell proliferation (Bcl2l1)

Bcl2l1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat anesthesia 6 99.28 Thalamus 1 96.96 cerebral cortex 1 96.08 isoflurane 1 86.60 Versed 1 86.12

Disease Link Frequency Relevance Heat Apoptosis 8 100.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Melatonin-induced neuroprotection was mediated, at least in part, via the inhibition of mitochondria-dependent apoptotic pathway since melatonin caused an up-regulation of the anti-apoptotic protein, bcl-X(L), reduction in anesthesia-induced cytochrome c release into the cytoplasm and a decrease in anesthesia-induced activation of caspase-3, an important step in the activation of DNAses and the formation of the apoptotic bodies.

Negative_regulation (inhibition) of Positive_regulation (caused) of bcl-X associated with anesthesia and apoptosis

1) Confidence 0.41 Published 2006 Journal Neurobiol. Dis. Section Abstract Doc Link 16289675 Disease Relevance 0.66 Pain Relevance 0.70

General Comments

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